The 6 high-affinity insulin-like growth factor binding proteins (IGFBPs) are multifunctional
proteins that modulate cell signaling through multiple pathways. Their canonical function at …

Insulin-like growth factor binding proteins (IGFBPs) and the associated signaling
components in the insulin-like growth factor (IGF) pathway regulate cell differentiation …

Renal inflammation is a critical pathophysiological characteristic of diabetic kidney disease
(DKD). The mechanism of the inflammatory response is complicated, and there are few …

Despite the increasing use of protoplasts in plant biotechnology research, shoot
regeneration from protoplasts remains challenging. In this study, we investigated the factors …

Simple Summary Merkel cell carcinoma (MCC) is a rare and aggressive skin cancer.
Developing targeted therapies for MCC requires increased understanding of the …

Although Kawasaki disease (KD) and multisystem inflammatory syndrome in children (MIS-
C) share some clinical manifestations, their cardiovascular outcomes are different, and this …

Cells that are exposed to harmful genetic damage, either from internal or external sources,
may undergo senescence if they are unable to repair their DNA. Senescence, characterized …

Linking clinical multi-omics with mechanistic studies may improve the understanding of rare
cancers. We leverage two precision oncology programs to investigate rhabdomyosarcoma …

Background Invasiveness is a very challenging clinical problem in nonfunctional pituitary
adenomas (NFPAs), and currently, there are no effective invasiveness-related molecular …

Introduction Insulin-like growth factor binding protein 5 (IGFBP5) exerts an essential
biological role in many processes, including apoptosis, cellular differentiation, growth, and …