Pathophysiology of chronic limb ischemia

F Simon, A Oberhuber, N Floros, P Düppers… - Gefässchirurgie, 2018 - Springer
Die chronisch arterielle Ischämie der unteren Extremitäten stellt ein alltägliches Problem in
gefäßchirurgischen Kliniken dar. In Deutschland sind etwa 3% aller Hospitalisierungen auf …

Acetyl-CoA carboxylase 1 regulates endothelial cell migration by shifting the phospholipid composition

DK Glatzel, A Koeberle, H Pein, K Löser, A Stark… - Journal of lipid …, 2018 - ASBMB
The enzyme acetyl-CoA carboxylase (ACC) plays a crucial role in fatty acid metabolism. In
recent years, ACC has been recognized as a promising drug target for treating different …

A multiscale model of complex endothelial cell dynamics in early angiogenesis

D Stepanova, HM Byrne, PK Maini… - PLoS computational …, 2021 - journals.plos.org
We introduce a hybrid two-dimensional multiscale model of angiogenesis, the process by
which endothelial cells (ECs) migrate from a pre-existing vascular bed in response to local …

Succinylated chitosan derivative restore HUVEC cells function damaged by TNF-α and high glucose in vitro and enhanced wound healing

Z Chen, M Yuan, H Li, L Li, B Luo, L Lu, Q Xiang… - International Journal of …, 2024 - Elsevier
The inflammation of chronic wounds plays a key hindering role in the wound healing
process. Slowing down the inflammatory response is significant for the repair of chronic …

Unraveling Endothelial Cell Migration: Insights into Fundamental Forces, Inflammation, Biomaterial Applications, and Tissue Regeneration Strategies

D Jerka, K Bonowicz, K Piekarska… - ACS Applied Bio …, 2024 - ACS Publications
Cell migration is vital for many fundamental biological processes and human pathologies
throughout our life. Dynamic molecular changes in the tissue microenvironment determine …

Planar-polarized semaphorin-5c and plexin A promote the collective migration of epithelial cells in Drosophila

CG Stedden, W Menegas, AL Zajac, AM Williams… - Current Biology, 2019 - cell.com
Collective migration of epithelial cells is essential for morphogenesis, wound repair, and the
spread of many cancers, yet how individual cells signal to one another to coordinate their …

Computational modeling of angiogenesis: The importance of cell rearrangements during vascular growth

D Stepanova, HM Byrne, PK Maini… - WIREs Mechanisms of …, 2024 - Wiley Online Library
Angiogenesis is the process wherein endothelial cells (ECs) form sprouts that elongate from
the pre‐existing vasculature to create new vascular networks. In addition to its essential role …

Junction-based lamellipodia drive endothelial cell rearrangements in vivo via a VE-cadherin-F-actin based oscillatory cell-cell interaction

I Paatero, L Sauteur, M Lee, AK Lagendijk… - Nature …, 2018 - nature.com
Angiogenesis and vascular remodeling are driven by extensive endothelial cell movements.
Here, we present in vivo evidence that endothelial cell movements are associated with …

Spatial-controlled coating of pro-angiogenic proteins on 3D porous hydrogels guides endothelial cell behavior

C Le Bao, H Waller, A Dellaquila, D Peters… - International Journal of …, 2022 - mdpi.com
In tissue engineering, the composition and the structural arrangement of molecular
components within the extracellular matrix (ECM) determine the physical and biochemical …

Ex Vivo treatment of coronary artery endothelial cells with serum post-exercise training offers limited protection against in vitro exposure to FEC-T chemotherapy

M Mclaughlin, KL Hesketh, SL Horgan… - Frontiers in …, 2023 - frontiersin.org
Background: Chemotherapy treatment for breast cancer associates with well-documented
cardiovascular detriments. Exercise has shown promise as a potentially protective …