Interleukin-6 is an inflammatory cytokine with wide-ranging biological effects. It has been
widely demonstrated that neuroinflammation plays a critical role in the development of …

Cancerous cells can originate in a number of different tissues such as prostate, breast and
lung, but often go undetected and are non-painful. Many types of cancers have a propensity …

The midbrain ventrolateral periaqueductal gray (VL‐PAG) is a key component that mediates
pain modulation. Although spinal cord glial cells appear to play an important role in chronic …

Chronic pain remains to be a clinical challenge due to insufficient therapeutic strategies.
Minocycline is a member of the tetracycline class of antibiotics, which has been used in …

Aim: To investigate the mechanisms underlying the anti-nociceptive effect of minocycline on
bone cancer pain (BCP) in rats. Methods: A rat model of BCP was established by inoculating …

Previously, we showed that activation of the spinal CXCL9, 10/CXCR3 pathway mediated
bone cancer pain (BCP) in rats. However, the cellular mechanism involved is poorly …

Cancer-induced bone pain (CIBP) is a common clinical problem in breast cancer patients
with bone metastasis. Recent studies shows chemokines are novel targets for treatment of …

Background Activation of adenosine monophosphate–activated kinase (AMPK) has been
associated with the inhibition of inflammatory nociception and the attenuation of morphine …

The majority of patients with terminal breast cancer show signs of bone metastasis, the most
common cause of pain in cancer. Clinically available drug treatment options for the relief of …

Multiple myeloma is a bone marrow neoplasia with an incidence of 6/100,000/year in
Europe. While the disease remains incurable, the development of novel treatments such as …