Mechanisms of resistance to chemotherapy in non-small cell lung cancer

HY Min, HY Lee - Archives of pharmacal research, 2021 - Springer
Non-small cell lung cancer (NSCLC), which represents 80–85% of lung cancer cases, is one
of the leading causes of human death worldwide. The majority of patients undergo an …

Drug efflux transporters and multidrug resistance in acute leukemia: therapeutic impact and novel approaches to mediation

CQ Xia, PG Smith - Molecular pharmacology, 2012 - ASPET
Multidrug resistance (MDR), which is mediated by multiple drug efflux ATP-binding cassette
(ABC) transporters, is a critical issue in the treatment of acute leukemia, with permeability …

Hybrid of niosomes and bio-synthesized selenium nanoparticles as a novel approach in drug delivery for cancer treatment

M Gharbavi, B Johari, N Mousazadeh, B Rahimi… - Molecular Biology …, 2020 - Springer
The current study intends to investigate a novel drug delivery system (DDS) based on
niosomes structure (NISM) and bovine serum albumin (BSA) which was formulated to BSA …

Identification of drug-resistant cancer cells in flow cytometry combining 3D holographic tomography with machine learning

D Pirone, L Xin, V Bianco, L Miccio, W Xiao… - Sensors and Actuators B …, 2023 - Elsevier
Identifying drug-resistant cancer cells is of fundamental importance to afford disease and
find the most effective therapies for the patients. Recently, label-free imaging flow cytometry …

Characterization of melanoma cell lines resistant to vemurafenib and evaluation of their responsiveness to EGFR-and MET-inhibitor treatment

E Dratkiewicz, A Simiczyjew… - International Journal of …, 2019 - mdpi.com
Constitutively active mutated BRAF kinase occurs in more than 40% of patients suffering
from melanoma. To block its activity, a specific inhibitor, vemurafenib, is applied as a …

Studies of the in vitro cytotoxic, antioxidant, lipase inhibitory and antimicrobial activities of selected Thai medicinal plants

C Kaewpiboon, K Lirdprapamongkol… - … and alternative medicine, 2012 - Springer
Background Traditional folk medicinal plants have recently become popular and are widely
used for primary health care. Since Thailand has a great diversity of indigenous (medicinal) …

Overcoming the diverse mechanisms of multidrug resistance in lung cancer cells by photodynamic therapy using pTHPP-loaded PLGA-lipid hybrid nanoparticles

S Pramual, K Lirdprapamongkol… - European Journal of …, 2020 - Elsevier
Multidrug resistance (MDR) and the spread of cancer cells (metastasis) are major causes
leading to failure of cancer treatment. MDR can develop in two main ways, with differences …

Label-free assessment of the drug resistance of epithelial ovarian cancer cells in a microfluidic holographic flow cytometer boosted through machine learning

L Xin, W Xiao, L Che, JJ Liu, L Miccio, V Bianco… - ACS …, 2021 - ACS Publications
About 75% of epithelial ovarian cancer (EOC) patients suffer from relapsing and develop
drug resistance after primary chemotherapy. The commonly used clinical examinations and …

Feroniellin A-induced autophagy causes apoptosis in multidrug-resistant human A549 lung cancer cells

C Kaewpiboon, S Surapinit… - International …, 2014 - spandidos-publications.com
During the screening of natural chemicals that can reverse multidrug resistance in human
A549 lung cancer cells resistant to etoposide (A549RT-eto), we discovered that Feroniellin A …

Label-free cell classification in holographic flow cytometry through an unbiased learning strategy

G Ciaparrone, D Pirone, P Fiore, L Xin, W Xiao, X Li… - Lab on a Chip, 2024 - pubs.rsc.org
Nowadays, label-free imaging flow cytometry at the single-cell level is considered the
stepforward lab-on-a-chip technology to address challenges in clinical diagnostics, biology …