The definition of hyperuricemia (HU) varies widely in different studies, which makes the
epidemiological reports somewhat inconsistent. HU remains the culprit of the pathogenesis …

Xanthine oxidase inhibitors such as allopurinol and febuxostat have been the mainstay
urate-lowering therapy (ULT) for treating hyperuricaemia in patients with gout. However, not …

Objectives Several recent observations have suggested that the prevalence of gout may be
increasing worldwide, but there are no recent data from the USA. We analysed the …

Objective: The Working Group on Uric Acid and Cardiovascular Risk of the Italian Society of
Hypertension conceived and designed an ad-hoc study aimed at searching for prognostic …

The process of aging population will inevitably increase age-related comorbidities including
chronic kidney disease (CKD). In light of this demographic transition, the lack of an age …

Значительное количество эпидемиологических исследований продемонстрировало,
что гиперурикемия в высокой степени связана с риском развития сердечно-сосудистых …

Fatigue causes deleterious effects to physical and mental health of human being and may
cause loss of lives. Therefore, the adverse effects of fatigue on individuals and the society …

Xanthine oxidase (EC 1.17. 3.2)(XO) is one of the main enzymatic sources that create
reactive oxygen species (ROS) in the living system. It is a dehydrogenase enzyme that …

Introduction Gout is a common, progressive, systemic inflammatory arthritis caused by
hyperuricemia. Current guidelines recommend that serum uric acid (sUA) levels be …

Gout is currently the most frequent cause of inflammatory arthritis worldwide. It results from
elevated serum urate and subsequent deposition of monosodium urate crystals in joints and …