The benefits of exercise training for cancer patients are becoming increasingly evident.
Physical exercise has been shown to reduce cancer incidence and inhibit tumor growth …

The three RAS genes—HRAS, NRAS and KRAS—are collectively mutated in one-third of
human cancers, where they act as prototypic oncogenes. Interestingly, there are rather …

KRAS-mutant pancreatic ductal adenocarcinoma (PDAC) is highly immunosuppressive and
resistant to targeted and immunotherapies. Among the different PDAC subtypes, basal-like …

Mammalian cells harness autophagy to eliminate physiological byproducts of metabolism
and cope with microenvironmental perturbations. Moreover, autophagy connects cellular …

Colorectal cancer (CRC) is characterized by prominent genetic and phenotypic
heterogeneity between patients. To facilitate high-throughput genetic testing and functional …

Hepatocellular carcinoma (HCC) is highly heterogeneous in nature and has been one of the
most common cancer types worldwide. To ensure repeatability of identified gene expression …

Research into the potential benefits of artificial intelligence for comprehending the intricate
biology of cancer has grown as a result of the widespread use of deep learning and …

Esophageal squamous-cell carcinoma (ESCC), one of the most prevalent and lethal
malignant disease, has a complex but unknown tumor ecosystem. Here, we investigate the …

Hundreds of heritable traits and diseases that are caused by germline aberrations in
ubiquitously expressed genes manifest in a remarkably limited number of cell types and …

The process of cell competition results in the elimination of cells that are viable but 'less
fit'than surrounding cells. Given the highly heterogeneous nature of our tissues, it seems …