Despite impressive efforts invested in epigenetic research in the last 50 years, clinical
applications are still lacking. Only a few university hospital centers currently use epigenetic …

Here we provide a detailed tutorial on CRISPR in vivo screening. Using the mouse as the
model organism, we introduce a range of CRISPR tools and applications, delineate general …

Sporadic gliomas in companion dogs provide a window on the interaction between
tumorigenic mechanisms and host environment. We compared the molecular profiles of …

Human oncoproteins promote transformation of cells into tumours by dysregulating the
signalling pathways that are involved in cell growth, proliferation and death. Although …

Background To develop a supervised machine learning (ML) algorithm predicting above-
versus below-median overall survival (OS) from diffusion-weighted imaging-derived …

Background The diverse and complex attributes of cancer have made it a daunting
challenge to overcome globally and remains to endanger human life. Detection of critical …

The notion of tumor microenvironment (TME) has been brought to the forefront of recent
scientific literature on cancer. However, there is no consensus on how to define and spatially …

In vitro 3D culture systems provide promising tools for screening novel therapies and
understanding drug resistance mechanisms in cancer because they are adapted for high …

Cancers of the same tissue-type but in anatomically distinct locations exhibit different
molecular dependencies for tumorigenesis. Proximal and distal colon cancers exemplify …

Mutations in KRAS are among the most frequent aberrations in cancer, including colon
cancer. KRAS direct targeting is daunting due to KRAS protein resistance to small molecule …