Genome research using appropriately collected pathological tissue samples is expected to
yield breakthroughs in the development of biomarkers and identification of therapeutic …

PTEN is one of the most commonly inactivated tumour suppressor genes in sporadic cancer.
Germline heterozygous PTEN gene alterations also underlie PTEN hamartoma tumour …

The hedgehog pathway, which plays a significant role in embryonic development and stem
cell regulation, is activated in gastrointestinal cancers. Chemotherapy is widely used in …

KRAS is one of the most commonly mutated oncogene and a negative predictive factor for a
number of targeted therapies. Therefore, the development of targeting strategies against …

Prediction of clinical drug response (CDR) of cancer patients, based on their clinical and
molecular profiles obtained prior to administration of the drug, can play a significant role in …

The extracellular matrix (ECM) plays a crucial role in regulating organ homeostasis. It
provides mechanical and biochemical cues directing cellular behaviour and, therefore, has …

Systemic therapies for pancreatic ductal adenocarcinoma (PDAC) remain unsatisfactory.
Clinical prognosis is particularly poor for tumor subtypes with activating aberrations in the …

DNA methylation is an epigenetic mechanism known to affect gene expression and aberrant
DNA methylation patterns have been described in cancer. However, only a small fraction of …

Are the receptor tyrosine kinase (RTK) and JAK-STAT-driven proliferation pathways
'parallel'or 'redundant'? And what about those of K-Ras4B versus N-Ras?'Parallel' …

One of the key challenges of cancer biology is to catalogue and understand the somatic
genomic alterations leading to cancer. Although alternative definitions and search methods …