Tubular injury and peripheral fibroblast activation are the hallmarks of chronic kidney
disease (CKD), suggesting intimate communication between the two types of cells …

Abstract Purpose of Review Oxygen is critical for the high output of energy (adenosine
triphosphate) generated by oxidative phosphorylation in the mitochondria, and when oxygen …

Aim: We performed a systematic review and network meta-analysis evaluating the safety
and efficacy of hypoxia-inducible factor prolyl hydroxylase inhibitors (HIF-PHIs) among …

What is known and objective Previous studies based on small‐sample clinical data proved
that short‐term use of hypoxia‐inducible factor prolyl hydroxylase (HIF‐PHD) inhibitors …

Actively dividing cells, including some cancers, rely on aerobic glycolysis rather than
oxidative phosphorylation to generate energy, a phenomenon termed the Warburg effect …

Objective To compare the effects of five hypoxia-inducible factor-prolyl hydroxylase domain
inhibitors (HIF-PHIs), two erythropoiesis-stimulating agents (ESAs), and placebo on iron …

Background Anaemia occurs in chronic kidney disease (CKD) and is more prevalent with
lower levels of kidney function. Anaemia in CKD is associated with death related to …

Introduction: Daprodustat, a novel hypoxia-inducible factor prolyl-hydroxylase inhibitor (HIF-
PHI), its efficacy and safety remain unclear. Thus, we conducted this meta-analysis aiming at …

Background: Vadadustat is a novel drug for treating anemia patients with chronic kidney
disease (CKD), but its effect and safety remain uncertain. This study aimed to summarize the …

The objective was to provide a comprehensive summary of existing evidence on the efficacy
and safety of hypoxia-inducible factor-prolyl hydroxylase inhibitors (HIF-PHIs) for the …