Interferon beta-1a sc at 25 years: a mainstay in the treatment of multiple sclerosis over the period of one generation
Introduction Interferon beta (IFN beta) preparations are an established group of drugs used
for immunomodulation in patients with multiple sclerosis (MS). Subcutaneously (sc) applied …
for immunomodulation in patients with multiple sclerosis (MS). Subcutaneously (sc) applied …
[HTML][HTML] Drugs targeting CD20 in multiple sclerosis: pharmacology, efficacy, safety, and tolerability
Currently, there are four monoclonal antibodies (mAbs) that target the cluster of
differentiation (CD) 20 receptor available to treat multiple sclerosis (MS): rituximab …
differentiation (CD) 20 receptor available to treat multiple sclerosis (MS): rituximab …
[HTML][HTML] Key characteristics of anti-CD20 monoclonal antibodies and clinical implications for multiple sclerosis treatment
The recent success of anti-CD20 monoclonal antibody therapies in the treatment of multiple
sclerosis (MS) has highlighted the role of B cells in the pathogenesis of MS. In people with …
sclerosis (MS) has highlighted the role of B cells in the pathogenesis of MS. In people with …
[HTML][HTML] How to understand the 95% confidence interval around the relative risk, odds ratio, and hazard ratio: as simple as it gets
C Andrade - The Journal of Clinical Psychiatry, 2023 - psychiatrist.com
Statistics such as the mean difference (MD), standardized mean difference (SMD), relative
risk (RR), odds ratio (OR), hazard ratio (HR), and others are meant to be examined along …
risk (RR), odds ratio (OR), hazard ratio (HR), and others are meant to be examined along …
[HTML][HTML] The CXCL13 Index as a predictive biomarker for activity in clinically isolated syndrome
SC Pike, F Gilli, AR Pachner - International Journal of Molecular Sciences, 2023 - mdpi.com
Multiple sclerosis (MS) is a clinically heterogenous disease. Currently, we cannot identify
patients with more active disease who may potentially benefit from earlier interventions …
patients with more active disease who may potentially benefit from earlier interventions …
[HTML][HTML] From Animal Models to Clinical Trials: The Potential of Antimicrobials in Multiple Sclerosis Treatment
MF Raghib, E Bernitsas - Biomedicines, 2023 - mdpi.com
Multiple sclerosis (MS) is a chronic, autoimmune, demyelinating disease of the central
nervous system (CNS). Microbes, including bacteria and certain viruses, particularly Epstein …
nervous system (CNS). Microbes, including bacteria and certain viruses, particularly Epstein …
Neoehrlichiosis associated with ocrelizumab in a patient with multiple sclerosis: A case report
RM Afzal, J Romme Christensen… - Multiple Sclerosis …, 2024 - journals.sagepub.com
Objective: To describe a case of neoehrlichiosis, an emerging opportunistic tick-borne
infection, in a patient with multiple sclerosis (MS) treated with ocrelizumab. Methods: This is …
infection, in a patient with multiple sclerosis (MS) treated with ocrelizumab. Methods: This is …
[HTML][HTML] B-cell targeted therapies in autoimmune encephalitis: mechanisms, clinical applications, and therapeutic potential
H Shang, X Shen, X Yu, J Zhang, Y Jia… - Frontiers in …, 2024 - frontiersin.org
Autoimmune encephalitis (AE) broadly refers to inflammation of the brain parenchyma
mediated by autoimmune mechanisms. In most patients with AE, autoantibodies against …
mediated by autoimmune mechanisms. In most patients with AE, autoantibodies against …
Evaluating the Therapeutic Potential of Ublituximab in the Treatment of MS: Design, Development and Place in Therapy
SJ Martin, M Guenette, J Oh - Drug Design, Development and …, 2024 - Taylor & Francis
B cells are critical to the pathogenesis of multiple sclerosis (MS), an autoimmune disease of
the central nervous system. B cell depletion using anti-CD20 monoclonal antibodies (mAbs) …
the central nervous system. B cell depletion using anti-CD20 monoclonal antibodies (mAbs) …
[HTML][HTML] Absence of Anti-Babesia microti antibody in commercial intravenous immunoglobulin (IVIG)
J Kostka, AS Maharjan, S Kumar… - PLOS Neglected …, 2024 - journals.plos.org
Background Babesiosis is a worldwide emerging protozoan infection that is associated with
a spectrum of disease severity from asymptomatic infection to severe organ damage and …
a spectrum of disease severity from asymptomatic infection to severe organ damage and …