Interferon beta-1a sc at 25 years: a mainstay in the treatment of multiple sclerosis over the period of one generation

UK Zettl, PS Rommer, O Aktas, T Wagner… - Expert review of …, 2023 - Taylor & Francis
Introduction Interferon beta (IFN beta) preparations are an established group of drugs used
for immunomodulation in patients with multiple sclerosis (MS). Subcutaneously (sc) applied …

[HTML][HTML] Drugs targeting CD20 in multiple sclerosis: pharmacology, efficacy, safety, and tolerability

AK Carlson, M Amin, JA Cohen - Drugs, 2024 - Springer
Currently, there are four monoclonal antibodies (mAbs) that target the cluster of
differentiation (CD) 20 receptor available to treat multiple sclerosis (MS): rituximab …

[HTML][HTML] Key characteristics of anti-CD20 monoclonal antibodies and clinical implications for multiple sclerosis treatment

SR Delgado, S Faissner, RA Linker, K Rammohan - Journal of neurology, 2024 - Springer
The recent success of anti-CD20 monoclonal antibody therapies in the treatment of multiple
sclerosis (MS) has highlighted the role of B cells in the pathogenesis of MS. In people with …

[HTML][HTML] How to understand the 95% confidence interval around the relative risk, odds ratio, and hazard ratio: as simple as it gets

C Andrade - The Journal of Clinical Psychiatry, 2023 - psychiatrist.com
Statistics such as the mean difference (MD), standardized mean difference (SMD), relative
risk (RR), odds ratio (OR), hazard ratio (HR), and others are meant to be examined along …

[HTML][HTML] The CXCL13 Index as a predictive biomarker for activity in clinically isolated syndrome

SC Pike, F Gilli, AR Pachner - International Journal of Molecular Sciences, 2023 - mdpi.com
Multiple sclerosis (MS) is a clinically heterogenous disease. Currently, we cannot identify
patients with more active disease who may potentially benefit from earlier interventions …

[HTML][HTML] From Animal Models to Clinical Trials: The Potential of Antimicrobials in Multiple Sclerosis Treatment

MF Raghib, E Bernitsas - Biomedicines, 2023 - mdpi.com
Multiple sclerosis (MS) is a chronic, autoimmune, demyelinating disease of the central
nervous system (CNS). Microbes, including bacteria and certain viruses, particularly Epstein …

Neoehrlichiosis associated with ocrelizumab in a patient with multiple sclerosis: A case report

RM Afzal, J Romme Christensen… - Multiple Sclerosis …, 2024 - journals.sagepub.com
Objective: To describe a case of neoehrlichiosis, an emerging opportunistic tick-borne
infection, in a patient with multiple sclerosis (MS) treated with ocrelizumab. Methods: This is …

[HTML][HTML] B-cell targeted therapies in autoimmune encephalitis: mechanisms, clinical applications, and therapeutic potential

H Shang, X Shen, X Yu, J Zhang, Y Jia… - Frontiers in …, 2024 - frontiersin.org
Autoimmune encephalitis (AE) broadly refers to inflammation of the brain parenchyma
mediated by autoimmune mechanisms. In most patients with AE, autoantibodies against …

Evaluating the Therapeutic Potential of Ublituximab in the Treatment of MS: Design, Development and Place in Therapy

SJ Martin, M Guenette, J Oh - Drug Design, Development and …, 2024 - Taylor & Francis
B cells are critical to the pathogenesis of multiple sclerosis (MS), an autoimmune disease of
the central nervous system. B cell depletion using anti-CD20 monoclonal antibodies (mAbs) …

[HTML][HTML] Absence of Anti-Babesia microti antibody in commercial intravenous immunoglobulin (IVIG)

J Kostka, AS Maharjan, S Kumar… - PLOS Neglected …, 2024 - journals.plos.org
Background Babesiosis is a worldwide emerging protozoan infection that is associated with
a spectrum of disease severity from asymptomatic infection to severe organ damage and …