Gonococcal defenses against antimicrobial activities of neutrophils

A Palmer, AK Criss - Trends in microbiology, 2018 - cell.com
Neisseria gonorrhoeae initiates a strong local immune response that is characterized by
copious recruitment of neutrophils to the site of infection. Neutrophils neutralize microbes by …

Gonococcal pelvic inflammatory disease: placing mechanistic insights into the context of clinical and epidemiological observations

SX Xu, SD Gray-Owen - The Journal of Infectious Diseases, 2021 - academic.oup.com
While infection by Neisseria gonorrhoeae is often asymptomatic in women, undetected
infections can ascend into the upper genital tract to elicit an inflammatory response that …

[HTML][HTML] Relative importance of soluble and microsomal epoxide hydrolases for the hydrolysis of epoxy-fatty acids in human tissues

C Morisseau, SD Kodani, SG Kamita, J Yang… - International journal of …, 2021 - mdpi.com
Epoxy-fatty acids (EpFAs) are endogenous lipid mediators that have a large breadth of
biological activities, including the regulation of blood pressure, inflammation, angiogenesis …

[HTML][HTML] The MtrCDE Efflux Pump Contributes to Survival of Neisseria gonorrhoeae From Human Neutrophils and Their Antimicrobial Components

JW Handing, SA Ragland, UV Bharathan… - Frontiers in …, 2018 - frontiersin.org
The mucosal inflammatory response to Neisseria gonorrhoeae (Gc) is characterized by
recruitment of neutrophils to the site of infection. Gc survives exposure to neutrophils by …

Development of ADS051, an oral, gut‐restricted, small molecule neutrophil modulator for the treatment of neutrophil‐mediated inflammatory diseases

CK Murphy, B Dixit, FB Oleson, RE Dolle… - FEBS Open …, 2023 - Wiley Online Library
Neutrophils are an essential component of the innate immune system; however,
uncontrolled neutrophil activity can lead to inflammation and tissue damage in acute and …

[HTML][HTML] Tissue Models for Neisseria gonorrhoeae Research—From 2D to 3D

M Heydarian, E Rühl, R Rawal… - Frontiers in Cellular and …, 2022 - frontiersin.org
Neisseria gonorrhoeae is a human-specific pathogen that causes gonorrhea, the second
most common sexually transmitted infection worldwide. Disease progression, drug …

Triple co-culture and perfusion bioreactor for studying the interaction between Neisseria gonorrhoeae and neutrophils: A novel 3D tissue model for bacterial infection …

M Heydarian, M Schweinlin… - Journal of Tissue …, 2021 - journals.sagepub.com
Gonorrhea, a sexually transmitted disease caused by the bacteria Neisseria gonorrhoeae, is
characterized by a large number of neutrophils recruited to the site of infection. Therefore …

Adherence Enables Neisseria gonorrhoeae to Overcome Zinc Limitation Imposed by Nutritional Immunity Proteins

JC Ray, A Smirnov, SA Maurakis… - Infection and …, 2022 - Am Soc Microbiol
Neisseria gonorrhoeae (Gc) must overcome the limitation of metals such as zinc to colonize
mucosal surfaces in its obligate human host. While the zinc-binding nutritional immunity …

Imaging Flow Cytometry Analysis of CEACAM Binding to Opa‐Expressing Neisseria gonorrhoeae

LM Werner, A Palmer, A Smirnov… - Cytometry Part …, 2020 - Wiley Online Library
Human carcinoembryonic antigen‐related cell adhesion molecules (CEACAMs) are a family
of receptors that mediate intercellular interactions. Pathogenic bacteria have ligands that …

Challenges and controversies concerning Neisseria gonorrhoeae-neutrophil interactions in pathogenesis

AK Criss, CA Genco, SD Gray-Owen, AE Jerse… - MBio, 2021 - Am Soc Microbiol
ABSTRACT The bacterium Neisseria gonorrhoeae (Ngo) is the main cause of the sexually
transmitted infection gonorrhea. The global incidence of 87 million new Ngo infections each …