Gonococcal defenses against antimicrobial activities of neutrophils
Neisseria gonorrhoeae initiates a strong local immune response that is characterized by
copious recruitment of neutrophils to the site of infection. Neutrophils neutralize microbes by …
copious recruitment of neutrophils to the site of infection. Neutrophils neutralize microbes by …
Gonococcal pelvic inflammatory disease: placing mechanistic insights into the context of clinical and epidemiological observations
SX Xu, SD Gray-Owen - The Journal of Infectious Diseases, 2021 - academic.oup.com
While infection by Neisseria gonorrhoeae is often asymptomatic in women, undetected
infections can ascend into the upper genital tract to elicit an inflammatory response that …
infections can ascend into the upper genital tract to elicit an inflammatory response that …
[HTML][HTML] Relative importance of soluble and microsomal epoxide hydrolases for the hydrolysis of epoxy-fatty acids in human tissues
Epoxy-fatty acids (EpFAs) are endogenous lipid mediators that have a large breadth of
biological activities, including the regulation of blood pressure, inflammation, angiogenesis …
biological activities, including the regulation of blood pressure, inflammation, angiogenesis …
[HTML][HTML] The MtrCDE Efflux Pump Contributes to Survival of Neisseria gonorrhoeae From Human Neutrophils and Their Antimicrobial Components
JW Handing, SA Ragland, UV Bharathan… - Frontiers in …, 2018 - frontiersin.org
The mucosal inflammatory response to Neisseria gonorrhoeae (Gc) is characterized by
recruitment of neutrophils to the site of infection. Gc survives exposure to neutrophils by …
recruitment of neutrophils to the site of infection. Gc survives exposure to neutrophils by …
Development of ADS051, an oral, gut‐restricted, small molecule neutrophil modulator for the treatment of neutrophil‐mediated inflammatory diseases
CK Murphy, B Dixit, FB Oleson, RE Dolle… - FEBS Open …, 2023 - Wiley Online Library
Neutrophils are an essential component of the innate immune system; however,
uncontrolled neutrophil activity can lead to inflammation and tissue damage in acute and …
uncontrolled neutrophil activity can lead to inflammation and tissue damage in acute and …
[HTML][HTML] Tissue Models for Neisseria gonorrhoeae Research—From 2D to 3D
M Heydarian, E Rühl, R Rawal… - Frontiers in Cellular and …, 2022 - frontiersin.org
Neisseria gonorrhoeae is a human-specific pathogen that causes gonorrhea, the second
most common sexually transmitted infection worldwide. Disease progression, drug …
most common sexually transmitted infection worldwide. Disease progression, drug …
Triple co-culture and perfusion bioreactor for studying the interaction between Neisseria gonorrhoeae and neutrophils: A novel 3D tissue model for bacterial infection …
M Heydarian, M Schweinlin… - Journal of Tissue …, 2021 - journals.sagepub.com
Gonorrhea, a sexually transmitted disease caused by the bacteria Neisseria gonorrhoeae, is
characterized by a large number of neutrophils recruited to the site of infection. Therefore …
characterized by a large number of neutrophils recruited to the site of infection. Therefore …
Adherence Enables Neisseria gonorrhoeae to Overcome Zinc Limitation Imposed by Nutritional Immunity Proteins
Neisseria gonorrhoeae (Gc) must overcome the limitation of metals such as zinc to colonize
mucosal surfaces in its obligate human host. While the zinc-binding nutritional immunity …
mucosal surfaces in its obligate human host. While the zinc-binding nutritional immunity …
Imaging Flow Cytometry Analysis of CEACAM Binding to Opa‐Expressing Neisseria gonorrhoeae
Human carcinoembryonic antigen‐related cell adhesion molecules (CEACAMs) are a family
of receptors that mediate intercellular interactions. Pathogenic bacteria have ligands that …
of receptors that mediate intercellular interactions. Pathogenic bacteria have ligands that …
Challenges and controversies concerning Neisseria gonorrhoeae-neutrophil interactions in pathogenesis
ABSTRACT The bacterium Neisseria gonorrhoeae (Ngo) is the main cause of the sexually
transmitted infection gonorrhea. The global incidence of 87 million new Ngo infections each …
transmitted infection gonorrhea. The global incidence of 87 million new Ngo infections each …