Usefulness and potential pitfalls of long-acting growth hormone analogs

KCJ Yuen, BS Miller, CL Boguszewski… - Frontiers in …, 2021 - frontiersin.org
Daily recombinant human GH (rhGH) is currently approved for use in children and adults
with GH deficiency (GHD) in many countries with relatively few side-effects. Nevertheless …

Influence of cultivation practices on the metabolism of cytokinin and its correlation in rice production

S Shah, L Cai, X Li, S Fahad… - Food and Energy …, 2023 - Wiley Online Library
Cytokinin (CTK) has an important regulatory effect on plant morphology, physiology, and
yield, and is one of the main factors regulating nitrogen absorption, transport, and …

Weekly somapacitan is effective and well tolerated in children with GH deficiency: the randomized phase 3 REAL4 trial

BS Miller, JC Blair, MH Rasmussen… - The Journal of …, 2022 - academic.oup.com
Context Somapacitan, a once-weekly reversible albumin-binding GH derivative, is evaluated
in children with GH deficiency (GHD). Objective To demonstrate efficacy and safety of …

Once-weekly somapacitan is effective and well tolerated in adults with GH deficiency: a randomized phase 3 trial

G Johannsson, MB Gordon… - The Journal of …, 2020 - academic.oup.com
Context Growth hormone (GH) replacement requires daily GH injections, which is
burdensome for some adult patients with GH deficiency (AGHD). Objective To demonstrate …

Effective GH replacement with somapacitan in children with GHD: REAL4 2-year results and after switch from daily GH

BS Miller, JC Blair, MH Rasmussen… - The Journal of …, 2023 - academic.oup.com
Context Somapacitan is a long-acting GH derivative for treatment of GH deficiency (GHD).
Objective Evaluate the efficacy and tolerability of somapacitan in children with GHD after 2 …

Once-weekly somapacitan vs daily GH in children with GH deficiency: results from a randomized phase 2 trial

L Sävendahl, T Battelino, M Brod… - The Journal of …, 2020 - academic.oup.com
Context Daily growth hormone (GH) injections can be burdensome for patients and carers.
Somapacitan is a long-acting, reversible albumin-binding GH derivative in development for …

Developments in the management of growth hormone deficiency: clinical utility of somapacitan

BS Miller, J Blair, R Horikawa, A Linglart… - Drug Design …, 2024 - Taylor & Francis
Growth hormone (GH) replacement therapy for growth hormone deficiency (GHD) in children
and adults has for over 25 years, until recently, been administered as daily injections. This …

[HTML][HTML] Long-acting growth hormone preparations and their use in children with growth hormone deficiency

V Pampanini, A Deodati, E Inzaghi… - Hormone research in …, 2023 - karger.com
Background: Daily recombinant human growth hormone (rhGH) is approved and marketed
worldwide to treat children and adults with GH deficiency and other conditions. Efficacy of …

Safety and convenience of once-weekly somapacitan in adult GH deficiency: a 26-week randomized, controlled trial

G Johannsson, U Feldt-Rasmussen… - European journal of …, 2018 - academic.oup.com
Objective Somapacitan is a reversible albumin-binding growth hormone (GH) derivative,
developed for once-weekly administration. This study aimed to evaluate the safety of once …

Long acting growth hormone (LAGH), an update

MS Grillo, J Frank, P Saenger - Frontiers in Pediatrics, 2023 - frontiersin.org
In 1957, Maurice Raben at Yale was able to isolate and purify growth hormone from
cadaveric pituitary glands. Pituitary growth hormone was the only way to treat children with …