Influenza A virus‐induced thymus atrophy differentially affects dynamics of conventional and regulatory T‐cell development in mice

Y Elfaki, PA Robert, C Binz, CS Falk… - European Journal of …, 2021 - Wiley Online Library
Foxp3+ Treg cells, which are crucial for maintenance of self‐tolerance, mainly develop
within the thymus, where they arise from CD25+ Foxp3–or CD25–Foxp3+ Treg cell …

Foxn1 is not essential for T‐cell development in teleosts

M Schorpp, JB Swann, I Hess, HC Ho… - European Journal of …, 2023 - Wiley Online Library
In mammals, T‐cell development depends on the activity of the Foxn1 transcription factor in
the thymic epithelium; mutations in the vertebrate‐specific Foxn1 gene are associated with …

Biomarkers of senescence during aging as possible warnings to use preventive measures

A Gasmi, S Chirumbolo, M Peana… - Current Medicinal …, 2021 - ingentaconnect.com
Human life expectancy is increasing significantly over time thanks to the improved possibility
for people to take care of themselves and the higher availability of food, drugs, hygiene …

[HTML][HTML] Morphometric Analysis of the Thymic Epithelial Cell (TEC) Network Using Integrated and Orthogonal Digital Pathology Approaches

MK Lagou, DG Argyris, S Vodopyanov… - bioRxiv, 2024 - ncbi.nlm.nih.gov
The thymus, a central primary lymphoid organ of the immune system, plays a key role in T
cell development. Surprisingly, the thymus is quite neglected with regards to standardized …

Outcomes of dogs with thymoma treated with intensity modulated stereotactic body radiation therapy or non‐modulated hypofractionated radiation therapy

E Trageser, T Martin, E Hoaglund… - Veterinary and …, 2022 - Wiley Online Library
Canine thymomas are routinely treated with radiotherapy (RT). In this study, we investigate
the response and toxicity of canine thymoma treated with intensity‐modulated stereotactic …

[HTML][HTML] Enigmatic thymus: Variations in anatomical localisation of thymic tissue as an easily misdiagnosed congenital anomaly in surgical practice

A Mayer, J Voller, I Varga - World Journal of Clinical Cases, 2024 - wjgnet.com
We point out the issue of differential diagnosis regarding the finding of ectopically localised
thymic tissue (a thymic cyst) in the neck. Thymic tissue can be found anywhere along its …

[HTML][HTML] iTRAQ-based quantitative proteomic analysis of low molybdenum inducing thymus atrophy and participating in immune deficiency-related diseases

Y Zhang, J Zhao, B Zhou, E Tian, W Tian… - … and Environmental Safety, 2021 - Elsevier
Molybdenum is a trace element with extremely uneven distribution in the environment. It
constitutes the active sites of molybdenum enzymes that can catalyze redox reactions in …

Thymic epithelial organoids mediate T cell development

T Hübscher, LF Lorenzo-Martín, T Barthlott, L Tillard… - bioRxiv, 2024 - biorxiv.org
Although the advent of organoids opened unprecedented perspectives for basic and
translational research, immune system-related organoids remain largely underdeveloped …

Interactions between thymic endothelial cells and thymocytes are influenced by growth hormone

MP Lins, IMMN Viana, S Smaniotto, MDS Reis - Growth Factors, 2020 - Taylor & Francis
Growth hormone (GH), in addition to its classic actions on growth and metabolism in the
body, exerts pleiotropic effects on the immune system, particularly on the thymus. The aim of …

[HTML][HTML] Structural and Functional Thymic Biomarkers Are Involved in the Pathogenesis of Thymic Epithelial Tumors: An Overview

E Gallo, MT Ramieri, M Marino - Immuno, 2022 - mdpi.com
The normal human thymus originates from the third branchial cleft as two paired anlages
that descend into the thorax and fuse on the midline of the anterior–superior mediastinum …