The measurement of body composition (BC) represents a valuable tool to assess nutritional
status in health and disease. The most used methods to evaluate BC in the clinical practice …

Introduction: The rising prevalence of obesity confronts clinicians with dosing problems in
the (extreme) overweight population. Obesity has a great impact on key organs that play a …

Introduction: Obesity is associated with many physiological changes. We review available
evidence regarding five commonly accepted assumptions to a priori predict the impact of …

Introduction Obesity is associated with many physiological changes. We review available
evidence regarding five commonly accepted assumptions to a priori predict the impact of …

Since in vitro studies and a preliminary clinical report suggested the efficacy of chloroquine
for COVID-19-associated pneumonia, there is increasing interest in this old antimalarial …

Aims For a given passively‐distributed lipophilic drug, the extent of in vivo distribution
(pharmacokinetic volume of distribution, Vd) in obese individuals increases in relation to the …

Aims Several studies have reported the under‐representation of women in clinical trials,
thereby challenging the external validity of the benefit/risk assessments of launched drugs …

It is well known that lifestyle changes can alter several physiological functions in the human
body. For exercise and diet, these effects are used sensibly in basic therapies, as in …

Micafungin is a selective inhibitor of the synthesis of fungal 1, 3-β-d-glucan, an essential
component of the fungal cell wall. It is available as a powder for infusion only and is …

Obesity is associated with comorbidities of which pharmacological treatment is needed.
Physiological changes associated with obesity may influence the pharmacokinetics of drugs …