[HTML][HTML] NRF2 and NF-қB interplay in cerebrovascular and neurodegenerative disorders: molecular mechanisms and possible therapeutic approaches

F Sivandzade, S Prasad, A Bhalerao, L Cucullo - Redox biology, 2019 - Elsevier
Electrophiles and reactive oxygen species (ROS) play a major role in modulating cellular
defense mechanisms as well as physiological functions, and intracellular signaling …

NRF2 as a therapeutic target in neurodegenerative diseases

MS Brandes, NE Gray - ASN neuro, 2020 - journals.sagepub.com
Increased reactive oxygen species production and oxidative stress have been implicated in
the pathogenesis of numerous neurodegenerative conditions including among others …

Characterization of glucosinolates in 80 broccoli genotypes and different organs using UHPLC-Triple-TOF-MS method

Z Li, S Zheng, Y Liu, Z Fang, L Yang, M Zhuang… - Food Chemistry, 2021 - Elsevier
We aimed to characterize and quantify glucosinolate compounds and contents in broccoli,
and a total of 80 genotypes and eight developmental organs were analyzed with UHPLC …

Epigenetics and neurodegeneration: role of early-life nutrition

R Gabbianelli, E Damiani - The Journal of nutritional biochemistry, 2018 - Elsevier
Neurodegeneration represents a global problem due to the progressive increase in the
aging population all over the world. The quality of life in aging and the cost for the health …

[HTML][HTML] Sulforaphane protects against unilateral ureteral obstruction-induced renal damage in rats by alleviating mitochondrial and lipid metabolism impairment

AK Aranda-Rivera, A Cruz-Gregorio, OE Aparicio-Trejo… - Antioxidants, 2022 - mdpi.com
Unilateral ureteral obstruction (UUO) is an animal rodent model that allows the study of
obstructive nephropathy in an accelerated manner. During UUO, tubular damage is induced …

Tilapia skin peptides restore cyclophosphamide-induced premature ovarian failure via inhibiting oxidative stress and apoptosis in mice

YT Zhao, H Yin, C Hu, J Zeng, X Shi, S Chen… - Food & Function, 2022 - pubs.rsc.org
Tilapia (Oreochromis mossambicus) skin high value-added compounds have not been fully
utilized in tilapia processing. Here, the protective effects of tilapia skin peptides (TSP) on …

[HTML][HTML] Role of Nrf2 in synaptic plasticity and memory in Alzheimer's disease

DA Davies, A Adlimoghaddam, BC Albensi - Cells, 2021 - mdpi.com
Nuclear factor erythroid 2-related factor 2 (Nrf2) is an important transcription factor that
reduces oxidative stress. When reactive oxygen species (ROS) or reactive nitrogen species …

Inhibitory effects of sulforaphane on NLRP3 inflammasome activation

C Kiser, CP Gonul, M Olcum, S Genc - Molecular immunology, 2021 - Elsevier
SFN, a dietary phytochemical, is a significant member of isothiocyanates present in
cruciferous vegetables at high levels in broccoli. It is a well-known activator of the Nrf2/ARE …

Cruciferous vegetables: rationale for exploring potential salutary effects of sulforaphane-rich foods in patients with chronic kidney disease

LFMF Cardozo, LA Alvarenga, M Ribeiro, L Dai… - Nutrition …, 2021 - academic.oup.com
Sulforaphane (SFN) is a sulfur-containing isothiocyanate found in cruciferous vegetables
(Brassicaceae) and a well-known activator of nuclear factor-erythroid 2-related factor 2 …

Neuroprotective effects of aucubin on hydrogen peroxide-induced toxicity in human neuroblastoma SH-SY5Y cells via the Nrf2/HO-1 pathway

Y chun Li, J cheng Hao, B Shang, C Zhao, L juan Wang… - Phytomedicine, 2021 - Elsevier
Background When redox balance is lost in the brain, oxidative stress can cause serious
damage that leads to neuronal loss, in congruence with neurodegenerative diseases …