Platelet activation and prothrombotic mediators at the nexus of inflammation and atherosclerosis: Potential role of antiplatelet agents
Platelets are central to inflammation-related manifestations of cardiovascular diseases
(CVD) such as atherosclerosis. Platelet-activating factor (PAF), thrombin, thromboxane A 2 …
(CVD) such as atherosclerosis. Platelet-activating factor (PAF), thrombin, thromboxane A 2 …
Platelet activating factor (PAF): a mediator of inflammation
Platelet‐activating factor (PAF) is a phospholipid‐derived mediator with an established role
in multiple inflammatory states. PAF is synthesized and secreted by multiple cell types and is …
in multiple inflammatory states. PAF is synthesized and secreted by multiple cell types and is …
Localized cardiac small molecule trajectories and persistent chemical sequelae in experimental Chagas disease
Z Liu, R Ulrich vonBargen, AL Kendricks… - Nature …, 2023 - nature.com
Post-infectious conditions present major health burdens but remain poorly understood. In
Chagas disease (CD), caused by Trypanosoma cruzi parasites, antiparasitic agents that …
Chagas disease (CD), caused by Trypanosoma cruzi parasites, antiparasitic agents that …
Micronutrients, phytochemicals and mediterranean diet: A potential protective role against COVID-19 through modulation of PAF actions and metabolism
P Detopoulou, CA Demopoulos, S Antonopoulou - Nutrients, 2021 - mdpi.com
The new coronavirus disease 2019 (COVID-19) pandemic is an emerging situation with high
rates of morbidity and mortality, in the pathophysiology of which inflammation and …
rates of morbidity and mortality, in the pathophysiology of which inflammation and …
COVID‐19, microthromboses, inflammation, and platelet activating factor
Recent articles report elevated markers of coagulation, endothelial injury, and
microthromboses in lungs from deceased COVID‐19 patients. However, there has been no …
microthromboses in lungs from deceased COVID‐19 patients. However, there has been no …
PAFAH2 suppresses synchronized ferroptosis to ameliorate acute kidney injury
Q Zhang, T Sun, F Yu, W Liu, J Gao, J Chen… - Nature chemical …, 2024 - nature.com
Synchronized ferroptosis contributes to nephron loss in acute kidney injury (AKI). However,
the propagation signals and the underlying mechanisms of the synchronized ferroptosis for …
the propagation signals and the underlying mechanisms of the synchronized ferroptosis for …
Protective effect of olive oil microconstituents in atherosclerosis: Emphasis on PAF implicated atherosclerosis theory
S Antonopoulou, CA Demopoulos - Biomolecules, 2023 - mdpi.com
Atherosclerosis is a progressive vascular multifactorial process. The mechanisms
underlining the initiating event of atheromatous plaque formation are inflammation and …
underlining the initiating event of atheromatous plaque formation are inflammation and …
Targeting the platelet-activating factor receptor (PAF-R): antithrombotic and anti-atherosclerotic nutrients
Platelet-activating factor (PAF) is a lipid mediator that interacts with its receptor (PAF-R) to
carry out cell signalling. However, under certain conditions the binding of PAF to PAF-R …
carry out cell signalling. However, under certain conditions the binding of PAF to PAF-R …
Inflammation and cardiovascular disease: are marine phospholipids the answer?
Since the discovery that Greenlandic Innuits had a lower risk of developing cardiovascular
diseases (CVD) due to their diet of fish and as a consequence high polyunsaturated fatty …
diseases (CVD) due to their diet of fish and as a consequence high polyunsaturated fatty …
Cardioprotective effect of red wine and grape pomace
ÓA Muñoz-Bernal, AJ Coria-Oliveros… - Food Research …, 2021 - Elsevier
Several studies have related moderate consumption of red wine with prevention of
cardiovascular diseases (CVD). According to epidemiological studies, those regions with …
cardiovascular diseases (CVD). According to epidemiological studies, those regions with …