Found in translation—Fibrosis in metabolic dysfunction–associated steatohepatitis (MASH)

S Wang, SL Friedman - Science translational medicine, 2023 - science.org
Metabolic dysfunction–associated steatohepatitis (MASH) is a severe form of liver disease
that poses a global health threat because of its potential to progress to advanced fibrosis …

[HTML][HTML] Non-alcoholic steatohepatitis (NASH) and organokines: What is now and what will be in the future

JPM Santos, MC Maio, MA Lemes, LF Laurindo… - International Journal of …, 2022 - mdpi.com
Non-alcoholic steatohepatitis (NASH) is characterized by steatosis, lobular inflammation,
and enlargement of the diameter of hepatocytes (ballooning hepatocytes), with or without …

Circulating hormones in biopsy-proven steatotic liver disease and steatohepatitis: A Multicenter Observational Study

L Valenzuela-Vallejo, P Chrysafi, M Kouvari… - Metabolism, 2023 - Elsevier
Background The role of metabolic/inflammatory hormonal systems in metabolic dysfunction
associated steatotic liver disease (MASLD) remains to be fully elucidated. Purpose To report …

Insulin-like growth factor-1 levels are associated with high comorbidity of metabolic disorders in obese subjects; a Japanese single-center, retrospective-study

H Kubo, S Sawada, M Satoh, Y Asai, S Kodama… - Scientific Reports, 2022 - nature.com
Insulin like growth factor-1 (IGF-1) plays important roles in metabolic functions, especially in
adulthood. Additionally, obese subjects are reportedly predisposed to having low absolute …

Digested protein from chia seed (Salvia hispanica L) prevents obesity and associated inflammation of adipose tissue in mice fed a high-fat diet

M Grancieri, TA Verediano, CT Sant'Ana, A de Assis… - PharmaNutrition, 2022 - Elsevier
Background and aim Overweight and obesity are associated with the development of
several health complications, such as diabetes, cancer, and cardiovascular disease. Chia …

Updates on novel pharmacotherapeutics for the treatment of nonalcoholic steatohepatitis

Y Yang, L Xie, N Zhang, D Zhou, T Liu… - Acta Pharmacologica …, 2022 - nature.com
Nonalcoholic steatohepatitis (NASH) is a progressive form of nonalcoholic fatty liver disease
(NAFLD), characterized with hepatocellular steatosis, ballooning, lobular inflammation …

The role of adiponectin for immune cell function in metabolic diseases

M Gao, D Cui, J Xie - Diabetes, Obesity and Metabolism, 2023 - Wiley Online Library
Adiponectin, as an indispensable regulator of the immune system, is the most abundant
adipokine and is mainly produced by white adipose tissue. Adiponectin mediates the …

Resveratrol and Dulaglutide ameliorate adiposity and liver dysfunction in rats with diet-induced metabolic syndrome: Role of SIRT-1/adipokines/PPARγ and IGF-1

HAMA Shamardl, NA Ibrahim, DH Merzeban… - DARU Journal of …, 2023 - Springer
Background Adiposity and non-alcoholic fatty liver disease (NAFLD) are common
characteristics of metabolic syndrome (MS). Understanding the underlying pathogenesis is …

Non-invasive diagnosis of non-alcoholic fatty liver disease: Current status and future perspective

JL Wang, SW Jiang, AR Hu, AW Zhou, T Hu, HS Li… - Heliyon, 2024 - cell.com
Non-alcoholic fatty liver disease (NAFLD) is the most common cause of chronic liver disease
throughout the world. Hepatocellular carcinoma (HCC) and liver cirrhosis can result from …

Target deconvolution of fenofibrate in nonalcoholic fatty liver disease using bioinformatics analysis

A Mahmoudi, AE Butler… - BioMed research …, 2021 - Wiley Online Library
Background. Nonalcoholic fatty liver disease (NAFLD) is a prevalent form of liver damage,
affecting~ 25% of the global population. NAFLD comprises a spectrum of liver pathologies …