More than two decades have elapsed since the publication of the first genome sequence of
Mycobacterium tuberculosis (Mtb) which, shortly thereafter, enabled methods to determine …

Tuberculosis (TB) disease can be characterized by genotypic and phenotypic complexity in
Mycobacterium tuberculosis bacilli within a single patient. This microbiological …

Phenotypic screens for bactericidal compounds are starting to yield promising hits against
tuberculosis. In this regard, whole-genome sequencing of spontaneous resistant mutants …

Tuberculosis (TB) is an infectious disease, infecting a quarter of world's population. Drug
resistant TB further exacerbates the grim scenario of the drying TB drug discovery pipeline …

Tuberculosis (TB) disease can be characterized by genotypic and phenotypic complexity in
Mycobacterium tuberculosis bacilli within a single patient. This microbiological …

Mycobacterium tuberculosis is the causative pathogen of the pulmonary disease
tuberculosis. Despite the availability of effective treatment programs, there is a global pursuit …

The stringent response is well conserved across bacterial species and is a key pathway
involved both in bacterial survival and virulence and in the induction of antibiotic tolerance in …

Interactions of bacteria with the human host are, in the vast majority of cases, beneficial for
both partners (1). In fact, humans are dependent on their microbial associates for nutrition …

The discovery of molecules that could shorten the treatment period of tuberculosis (TB)
holds the promise of improving the current regimen. Polyamines are organic polycationic …

The long-term treatment of tuberculosis (TB) sometimes leads to nonadherence to treatment,
resulting in multidrug-resistant (MDR) and extensively drug-resistant (XDR) tuberculosis …