Septins are an integral component of the cytoskeleton, assembling into higher-order
oligomers and filamentous polymers that associate with actin filaments, microtubules and …

In order to fully understand any complex biochemical system from a mechanistic point of
view, it is necessary to have access to the three-dimensional structures of the molecular …

The actin and microtubule cytoskeletons comprise a variety of networks with distinct
architectures, dynamics and protein composition. A fundamental question in eukaryotic cell …

Septins are GTP-binding and membrane-interacting proteins with a highly conserved
domain structure involved in various cellular processes, including cytoskeleton organization …

The ability of cells to sense and communicate their shape is central to many of their
functions. Much is known about how cells generate complex shapes, yet how they sense …

Septins are cytoskeletal proteins conserved from algae and protists to mammals. A unique
feature of septins is their presence as heteromeric complexes that polymerize into filaments …

Septins are conserved GTP-binding cytoskeletal proteins that polymerize into filaments by
end-to-end joining of hetero-oligomeric complexes. In human cells, both hexamers and …

Septins are GTP-binding proteins that are evolutionarily and structurally related to the RAS
oncogenes. Septin expression levels are altered in many cancers and new advances point …

Septins are a unique family of GTPases, which were discovered 50 years ago as essential
genes for the asymmetric cell shape and division of budding yeast. Septins assemble into …

Male infertility has become a worldwide health problem, but the etiologies of most cases are
still unknown. SEPT12, a GTP-binding protein, is involved in male fertility. Two SEPT12 …