The emerging threat of (micro) thrombosis in COVID-19 and its therapeutic implications

JD McFadyen, H Stevens, K Peter - Circulation research, 2020 - Am Heart Assoc
The recent emergence of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2)
and the ensuing global pandemic has presented a health emergency of unprecedented …

COVID–19-associated coagulopathy: An exploration of mechanisms

ME Colling, Y Kanthi - Vascular Medicine, 2020 - journals.sagepub.com
An ongoing global pandemic of viral pneumonia (coronavirus disease [COVID-19]), due to
the virus SARS-CoV-2, has infected millions of people and remains a threat to many more …

[HTML][HTML] Neutrophil extracellular traps in COVID-19

Y Zuo, S Yalavarthi, H Shi, K Gockman, M Zuo… - JCI insight, 2020 - ncbi.nlm.nih.gov
In severe cases of coronavirus disease 2019 (COVID-19), viral pneumonia progresses to
respiratory failure. Neutrophil extracellular traps (NETs) are extracellular webs of chromatin …

Neutrophil calprotectin identifies severe pulmonary disease in COVID-19

H Shi, Y Zuo, S Yalavarthi, K Gockman… - Journal of Leucocyte …, 2021 - academic.oup.com
Severe cases of coronavirus disease 2019 (COVID-19) are regularly complicated by
respiratory failure. Although it has been suggested that elevated levels of blood neutrophils …

Biomarkers for acute respiratory distress syndrome and prospects for personalised medicine

S Spadaro, M Park, C Turrini, T Tunstall… - Journal of …, 2019 - Springer
Acute lung injury (ALI) affects over 10% of patients hospitalised in critical care, with acute
respiratory distress syndrome (ARDS) being the most severe form of ALI and having a …

IFN signaling and neutrophil degranulation transcriptional signatures are induced during SARS-CoV-2 infection

BA Rosa, M Ahmed, DK Singh… - Communications …, 2021 - nature.com
SARS-CoV-2 virus has infected more than 92 million people worldwide resulting in the
Coronavirus disease 2019 (COVID-19). Using a rhesus macaque model of SARS-CoV-2 …

Acute respiratory distress syndrome as an organ phenotype of vascular microthrombotic disease: based on hemostatic theory and endothelial molecular pathogenesis

JC Chang - Clinical and Applied Thrombosis/Hemostasis, 2019 - journals.sagepub.com
Acute respiratory distress syndrome (ARDS) is a life-threatening noncardiogenic circulatory
disorder of the lungs associated with critical illnesses such as sepsis, trauma, and immune …

[HTML][HTML] Supervised machine learning for the early prediction of acute respiratory distress syndrome (ARDS)

S Le, E Pellegrini, A Green-Saxena, C Summers… - Journal of Critical …, 2020 - Elsevier
Purpose Acute respiratory distress syndrome (ARDS) is a serious respiratory condition with
high mortality and associated morbidity. The objective of this study is to develop and …

Ultra-protective ventilation reduces biotrauma in patients on venovenous extracorporeal membrane oxygenation for severe acute respiratory distress syndrome

S Rozencwajg, A Guihot, G Franchineau… - Critical care …, 2019 - journals.lww.com
Design: Randomized clinical trial. Settings: Nine-month monocentric study. Patients: Severe
acute respiratory distress syndrome patients on venovenous extracorporeal membrane …

[HTML][HTML] Biomarkers for the acute respiratory distress syndrome: how to make the diagnosis more precise

MI García-Laorden, JA Lorente, C Flores… - Annals of …, 2017 - ncbi.nlm.nih.gov
The acute respiratory distress syndrome (ARDS) is an acute inflammatory process of the
lung caused by a direct or indirect insult to the alveolar-capillary membrane. Currently …