A researcher's guide to preclinical mouse NASH models
Non-alcoholic fatty liver disease (NAFLD) and its inflammatory form, non-alcoholic
steatohepatitis (NASH), have quickly risen to become the most prevalent chronic liver …
steatohepatitis (NASH), have quickly risen to become the most prevalent chronic liver …
[HTML][HTML] Remodeling of the immune and stromal cell compartment by PD-1 blockade in mismatch repair-deficient colorectal cancer
J Li, C Wu, H Hu, G Qin, X Wu, F Bai, J Zhang, Y Cai… - Cancer Cell, 2023 - cell.com
Immune checkpoint inhibitor (ICI) therapy can induce complete responses in mismatch
repair-deficient and microsatellite instability-high (d-MMR/MSI-H) colorectal cancers (CRCs) …
repair-deficient and microsatellite instability-high (d-MMR/MSI-H) colorectal cancers (CRCs) …
Inflammation and cancer: triggers, mechanisms, and consequences
FR Greten, SI Grivennikov - Immunity, 2019 - cell.com
Inflammation predisposes to the development of cancer and promotes all stages of
tumorigenesis. Cancer cells, as well as surrounding stromal and inflammatory cells, engage …
tumorigenesis. Cancer cells, as well as surrounding stromal and inflammatory cells, engage …
Targeting cancer-promoting inflammation—have anti-inflammatory therapies come of age?
The immune system has crucial roles in cancer development and treatment. Whereas
adaptive immunity can prevent or constrain cancer through immunosurveillance, innate …
adaptive immunity can prevent or constrain cancer through immunosurveillance, innate …
From NASH to HCC: current concepts and future challenges
Caloric excess and sedentary lifestyle have led to a global epidemic of obesity and
metabolic syndrome. The hepatic consequence of metabolic syndrome and obesity …
metabolic syndrome. The hepatic consequence of metabolic syndrome and obesity …
B cells, plasma cells and antibody repertoires in the tumour microenvironment
GV Sharonov, EO Serebrovskaya… - Nature Reviews …, 2020 - nature.com
Recent data show that B cells and plasma cells located in tumours or in tumour-draining
lymph nodes can have important roles in shaping antitumour immune responses. In tumour …
lymph nodes can have important roles in shaping antitumour immune responses. In tumour …
NAFLD-driven HCC: Safety and efficacy of current and emerging treatment options
In light of a global rise in obesity and type 2 diabetes, non-alcoholic fatty liver disease
(NAFLD) and non-alcoholic steatohepatitis (NASH) represent an increasingly important …
(NAFLD) and non-alcoholic steatohepatitis (NASH) represent an increasingly important …
Immunosuppressive mechanisms of regulatory B cells
D Catalán, MA Mansilla, A Ferrier, L Soto… - Frontiers in …, 2021 - frontiersin.org
Regulatory B cells (Bregs) is a term that encompasses all B cells that act to suppress
immune responses. Bregs contribute to the maintenance of tolerance, limiting ongoing …
immune responses. Bregs contribute to the maintenance of tolerance, limiting ongoing …
Global chemical effects of the microbiome include new bile-acid conjugations
A mosaic of cross-phylum chemical interactions occurs between all metazoans and their
microbiomes. A number of molecular families that are known to be produced by the …
microbiomes. A number of molecular families that are known to be produced by the …
Reshaping the systemic tumor immune environment (STIE) and tumor immune microenvironment (TIME) to enhance immunotherapy efficacy in solid tumors
The development of combination immunotherapy based on the mediation of regulatory
mechanisms of the tumor immune microenvironment (TIME) is promising. However, a deep …
mechanisms of the tumor immune microenvironment (TIME) is promising. However, a deep …