Diploidy is a fundamental genetic feature in mammals, in which haploid cells normally arise
only as post-meiotic germ cells that serve to ensure a diploid genome upon fertilization …

Replacement of mitochondria through nuclear transfer between oocytes of two different
women has emerged recently as a strategy for preventing inheritance of mtDNA diseases …

In recent years increasing numbers of women from wealthy countries have turned to egg
donation, egg freezing, and in vitro fertilization to become pregnant, especially later in life …

Transcription factor-induced reprogramming of specialized cells into other cell types and to
pluripotency has revolutionized our thinking about cell plasticity, differentiation, and stem …

An examination of a decade and a half of political controversy, ethical debate, and scientific
progress in stem cell research. After a decade and a half, human pluripotent stem cell …

Summary Expression of Oct3/4, Sox2, Klf4, and c-Myc (OSKM) can reprogram somatic cells
into induced pluripotent stem cells (iPSCs). Somatic cell nuclear transfer (SCNT) can also be …

Somatic cell nuclear transfer (SCNT) has been an area of interest in the field of stem cell
research and regenerative medicine for the past 20 years. The main biological goal of SCNT …

It is well known that maternal ageing not only causes increased spontaneous abortion and
reduced fertility, but it is also a high genetic disease risk. Although assisted reproductive …

The development of methods to derive induced pluripotent stem cells (iPSCs) has propelled
stem cell research, and has the potential to revolutionize many areas of medicine, including …

STUDY QUESTION How did the field of stem cell research develop in the years following the
derivation of the first human embryonic stem cell (hESC) line? SUMMARY ANSWER …