Establishment of embryonic stem cell (ESC) lines has been successful in mouse and
human, but not in farm animals. Development of direct reprogramming technology offers an …

Regeneration of the nervous system requires either the repair or replacement of nerve cells
that have been damaged by injury or disease. While lower organisms possess extensive …

The generation of pluripotent stem cells by somatic cell nuclear transfer (SCNT) has recently
been achieved in human cells and sparked new interest in this technology. The authors …

Type 2 diabetes, characterized by dysfunction of pancreatic β-cells and insulin resistance in
peripheral organs, accounts for more than 90% of all diabetes. Despite current …

Embryonic stem cells (ESCs) are a hallmark of ideal pluripotent stem cells. Epigenetic
reprogramming of induced pluripotent stem cells (iPSCs) has not been fully accomplished …

The boundaries of embryonic stem cell (ESC) research have extended considerably in
recent years in several important ways. Alongside a deeper understanding of the pluripotent …

The field of pluripotent stem cells (PSCs) is in a state of dynamic flux driven by significant
advances in the derivation of specific phenotypes from embryonic stem cells, breakthroughs …

Humans are diploid organisms, and triploidy in human embryos is responsible for∼ 10% of
spontaneous miscarriages. Surprisingly, some pregnancies proceed to triploid newborns …

Somatic cells can be reprogrammed to a pluripotent state by nuclear transfer into oocytes,
yet developmental arrest often occurs. While incomplete transcriptional reprogramming is …

Derivation of human embryonic stem cell (hES) lines in 1998 was not only a major
technological breakthrough in the field of regenerative medicine; it also triggered a …