Zinc finger proteins in the war on gastric cancer: Molecular mechanism and clinical potential

S Liu, X Liu, X Lin, H Chen - Cells, 2023 - mdpi.com
According to the 2020 global cancer data released by the World Cancer Research Fund
(WCRF) International, gastric cancer (GC) is the fifth most common cancer worldwide, with …

AKIP1 accelerates glioblastoma progression through stabilizing EGFR expression

S Wan, C Liu, C Li, Z Wang, G Zhao, J Li, W Ran… - Oncogene, 2023 - nature.com
Abstract A Kinase Interacting Protein 1 (AKIP1) is found to be overexpressed in a variety of
human cancers and associated with patients' worse prognosis. Several studies have …

HECTD3 regulates the tumourigenesis of glioblastoma by polyubiquitinating PARP1 and activating EGFR signalling pathway

G Zhang, R Tan, S Wan, R Yang, X Hu, E Zhao… - British Journal of …, 2022 - nature.com
Background The E3 ubiquitin ligase HECTD3 is a homologue of the E6-related protein
carboxyl terminus, which plays a crucial role in biological processes and tumourigenesis …

[HTML][HTML] TRAF4 promotes the proliferation of glioblastoma by stabilizing SETDB1 to activate the AKT pathway

H Gu, S Zhu, C Peng, Z Wei, Y Shen, C Yuan… - International Journal of …, 2022 - mdpi.com
The process of ubiquitination regulates the degradation, transport, interaction, and
stabilization of substrate proteins, and is crucial for cell signal transduction and function. TNF …

OTUD4 promotes the progression of glioblastoma by deubiquitinating CDK1 and activating MAPK signaling pathway

M Ci, G Zhao, C Li, R Liu, X Hu, J Pan, Y Shen… - Cell Death & …, 2024 - nature.com
Abstract Glioblastoma, IDH-Wild type (GBM, CNS WHO Grade 4) is a highly heterogeneous
and aggressive primary malignant brain tumor with high morbidity, high mortality, and poor …

A new CCCH-type zinc finger-related lncRNA signature predicts the prognosis of clear cell renal cell carcinoma patients

C Shen, Z Chen, J Jiang, Y Zhang, W Xu, R Peng… - Frontiers in …, 2022 - frontiersin.org
Background: Clear cell renal cell carcinoma (ccRCC) is the main component of renal cell
carcinoma (RCC), and advanced ccRCC frequently indicates a poor prognosis. The …

Nonstructural maintenance of chromatin condensin I complex subunit G promotes the progression of glioblastoma by facilitating Poly (ADP-ribose) polymerase 1 …

J Hou, P Huang, M Xu, H Wang, Y Shao… - Neuro …, 2023 - academic.oup.com
Background Nonstructural maintenance of chromatin condensin I complex subunit G
(NCAPG), also known as non-structural maintenance of chromosomes condensin I complex …

RAI14 promotes melanoma progression by regulating the FBXO32/c-MYC pathway

J Xu, P Shi, F Xia, X Zhao, J Chen, R Geng… - International Journal of …, 2022 - mdpi.com
Melanoma originates from the malignant transformation of melanocytes. Compared with
other skin cancers, melanoma has a higher fatality rate. The 5-year survival rate of patients …

SERPINE2 promotes liver cancer metastasis by inhibiting c‐Cbl‐mediated EGFR ubiquitination and degradation

S Zhang, X Jia, H Dai, X Zhu, W Song… - Cancer …, 2024 - Wiley Online Library
Background Liver cancer is a malignancy with high morbidity and mortality rates. Serpin
family E member 2 (SERPINE2) has been reported to play a key role in the metastasis of …

[HTML][HTML] GRIK1 promotes glioblastoma malignancy and is a novel prognostic factor of poor prognosis

G Hou, X Xu, W Hu - Oncology Research, 2024 - ncbi.nlm.nih.gov
Primary tumors of the central nervous system (CNS) are classified into over 100 different
histological types. The most common type of glioma is derived from astrocytes, and the most …