PHF12 regulates HDAC1 to promote tumorigenesis via EGFR/AKT signaling pathway in non-small cell lung cancer

Y Kong, H Zhou, M Ge, H Lin, Y Wang, R Yao, Q Wang… - 2023 - researchsquare.com
Background: Lung cancer stands as the second most prevalent malignant neoplasm
worldwide. Addressing the underlying mechanisms propelling the progression of non-small …

TRIP13 regulates progression of gastric cancer through mediating ubiquitination modification of DDX21

G Zhang, R Yang, B Wang, Q Yan, P Zhao, J Zhang… - 2024 - researchsquare.com
GC (Gastric cancer) is one of the most common malignant tumors, with over 95% of gastric
cancer patients being adenocarcinoma and most gastric cancer patients having no obvious …

Design and synthesis of novel EGFR kinase inhibitors for the treatment of EGFR C797S mutation in non-small cell lung cancer

W Nie, M Wang, Z Xia, C Wang, H Nie, S Zhang, J Qiu… - 2024 - researchsquare.com
Third-generation cutaneous growth factor receptor tyrosine kinase inhibitors have led to
impressive advances in the treatment of non-small cell lung cancer. However, acquired …