The intercalated disc (ID) is a highly specialized structure that connects cardiomyocytes via
mechanical and electrical junctions. Although described in some detail by light microscopy …

2 Gardner et al Sympathetic Remodeling and Arrhythmias excitability of postganglionic
neurons may also contribute to elevated adrenergic transmission in the heart. Neuronal cell …

Obesity is associated with elevated risk of heart disease. A solid understanding of the safety
and potential adverse effects of high-fat, low-carbohydrate diet (HFLCD) similar to that used …

Background: Obesity/hyperlipidemia is closely related to both atrial and ventricular
arrhythmias. CaMKII, a multifunctional serine/threonine kinase, has been involved in cardiac …

Cardioprotection by ischemic preconditioning (IP) was abolished in connexin 43 (Cx43)-
deficient mice due to loss of Cx43 located in mitochondria rather than at the sarcolemma. IP …

We aimed to explore whether specific high-sucrose intake in older female rats affects
myocardial electrical coupling protein, connexin-43 (Cx43), protein kinase C (PKC) …

Obesity with associated metabolic disturbances worsens ischaemic heart disease outcomes,
and rodent studies confirm that obesity with insulin-resistance impairs myocardial resistance …

High-fat, low-carbohydrate diets (HFLCD) are often eaten by humans for a variety of
reasons, but the effects of such diets on the heart are incompletely understood. We …

Obesity increases the risk of arrhythmias and sudden cardiac death, but the mechanisms are
unknown. This study tested the hypothesis that obesity-induced cardiac sympathetic …

Obesity has been demonstrated to be linked to atrial fibrillation (AF) with atrial enlargement
and tissue fibrosis. Long-term high calorie intake is the main reason for the prevalence of …