Liver diseases are one of the main causes of death, and their ever-increasing prevalence is
threatening to cause significant damage both to individuals and society as a whole. This …

Fitness of cells is dependent on protein homeostasis which is maintained by cooperative
activities of protein chaperones and proteolytic machinery. Upon encountering protein …

Background The mechanism of cuproptosis has recently been reported in lipoylated proteins
of the tricarboxylic acid (TCA) cycle. Besides, the role of copper was previously recognized …

Hepatocellular carcinoma (HCC) is one of the most common and deadly tumors worldwide.
Management of HCC depends on reliable biomarkers for screening, diagnosis, and …

Objective. Triple negative breast cancer (TNBC) is a kind of cancer that endangers the lives
of women all over the world in the 21st century. Heat shock protein member 8 (HSPA8) is the …

Primary liver cancers (PLC), including hepatocellular carcinoma (HCC) and
cholangiocarcinoma (CCA), are among the leading causes of cancer-related mortality …

Teratozoospermia is a significant cause of male infertility, but the pathogenic mechanism of
acephalic spermatozoa syndrome (ASS), one of the most severe teratozoospermia, remains …

Heat shock protein family A member 8 (HSPA8) participates in the folding or degradation of
misfolded proteins under stress and plays critical roles in cancer. In this study, we …

Remarkable advances have been made recently in the area of liver regeneration. Even
though liver regeneration after liver resection has been widely researched, new clinical …

Introduction Gastric cancer (GC) is one of the leading causes of cancer-related death
worldwide. Recently, targeted therapies including PD1 (programmed cell death 1) …