Aging is characterized by systemic chronic inflammation, which is accompanied by cellular
senescence, immunosenescence, organ dysfunction, and age-related diseases. Given the …

The aging and elderly population are particularly susceptible to cardiovascular disease. Age
is an independent risk factor for cardiovascular disease (CVD) in adults, but these risks are …

Cardiovascular diseases create an important burden on the public health systems,
especially in the elderly, mostly because this group of patients frequently suffer from multiple …

The extracellular matrix (ECM) is an essential component of the heart that imparts
fundamental cellular processes during organ development and homeostasis. Most …

Fibrosis is a pathologic process characterized by the replacement of parenchymal tissue by
large amounts of extracellular matrix, which may lead to organ dysfunction and even death …

Aging-induced pro-inflammatory phenotypic alterations of the cerebral vasculature critically
contribute to the pathogenesis of vascular cognitive impairment. Cellular senescence is a …

The global population above 60 years has been growing exponentially in the last decades,
which is accompanied by an increase in the prevalence of age‐related chronic diseases …

Cardiovascular Disease (CVD) is the most common cause of death in industrialized
countries, and myocardial infarction (MI) is a major CVD with significant morbidity and …

Arrhythmogenic cardiomyopathy (ACM) is an inherited progressive cardiac disease. Many
patients with ACM harbor mutations in desmosomal genes, predominantly in plakophilin-2 …

Understanding molecular mechanisms involved in vascular aging is essential to develop
novel interventional strategies for treatment and prevention of age-related vascular …