Diabetes and cognitive dysfunction, ranging from mild cognitive impairment to dementia,
often coexist in individuals over 65 years of age. Vascular contributions to cognitive …

The aim of this work was to systematically study the effect of freeze-drying of bottom-up
processed cilostazol nanosuspension on the particle size after redispersion. Several …

Nanosizing is an approach to improve the dissolution rate of poorly soluble drugs. The first
aim of this work was to develop nanosuspension of cilostazol with liquid antisolvent …

Stroke is one of the most serious problems that seriously affect people's health and brings
huge economic burden to society. The development of new nanocarriers with desired …

Autoimmune hepatitis (AIH) is a life-threatening disorder currently treated with nonspecific
immunosuppressive drugs. It is postulated that phosphodiesterase (PDE) inhibitors, as …

Abstract Cilostazol (CLZ), an anti-platelet agent, is primarily used following the onset of
cerebral infarction. However, as CLZ is only marginally soluble in water, a strategy for …

Polymeric nanoparticles are investigated as drug delivery devices to overcome
physicochemical and pharmacokinetic (PK) problems. Many drugs were found to be drug …

Indomethacin (IMC)-induced gastrointestinal (GI) injuries are more common in rheumatoid
arthritis (RA) patients than in other IMC users, and the overexpression of nitric oxide (NO) via …

Cilostazol (CIL) exerted a protective effect by promoting blood–brain barrier integrity as well
as improving the status of neurological dysfunctions following cerebral ischemia/reperfusion …

itory effect of a polymer on the crystallization of supersaturated cilostazol using solvent-shift
method, 35 we prepared a solution of cilostazol at 25 mg/mL in dimethyl sulfoxide (DMSO) …