The role of progesterone and the progesterone receptor in cancer: progress in the last 5 years

JH Check, DL Check - Expert Review of Endocrinology & …, 2023 - Taylor & Francis
Introduction Patients with various advanced cancers devoid of nuclear progesterone
receptors (nPR) have demonstrated increased quality and length of life when treated with …

Lung cancer–standard therapy and the use of a novel, highly effective, well tolerated, treatment with progesterone receptor modulators

JH Check, T Poretta, D Check… - Anticancer Research, 2023 - ar.iiarjournals.org
The most recent successful advances in lung cancer therapy have directly and increasingly
focused on personalized tumor genetic/epigenetic/immunologic profiling, and the …

Therapy aimed to suppress the production of the immunosuppressive protein progesterone induced blocking factor (PIBF) may provide palliation and/or increased …

JH Check, D Check - Anticancer Research, 2019 - ar.iiarjournals.org
Progesterone induced blocking factor (PIBF) is a unique protein that is not present in normal
cells, but is found predominantly in rapidly growing cells of the fetal placental unit or cancer …

New insights as to why progesterone receptor modulators, such as mifepristone, seem to be more effective in treating cancers that are devoid of the classical nuclear …

JH Check, D Check - Anticancer Research, 2021 - ar.iiarjournals.org
Mifepristone treatment for advanced cancer has demonstrated considerable improvement in
both length and quality of life in patients who no longer have any other treatment options …

A hypothetical model suggesting some possible ways that the progesterone receptor may be involved in cancer proliferation

JH Check, DL Check - International Journal of Molecular Sciences, 2021 - mdpi.com
Cancer and the fetal-placental semi-allograft share certain characteristics, eg, rapid
proliferation, the capacity to invade normal tissue, and, related to the presence of antigens …

Treatment with mifepristone allows a patient with end-stage pancreatic cancer in hospice on a morphine drip to restore a decent quality of life

JH Check, D Check, MD Srivastava, T Poretta… - Anticancer …, 2020 - ar.iiarjournals.org
Background: There is evidence that a unique immunomodulatory protein, known as the
progesterone induced blocking factor (PIBF), is utilized by a large variety of cancers to …

[PDF][PDF] Prolonged high-quality life in patients with non-small cell lung cancer treated with mifepristone who advanced despite osimertinib

DL Check, JH Check, T Poretta, J Aikins… - Cancer Sci Res, 2020 - scivisionpub.com
Though representing only, a minority of cases of non-small cell lung cancer (NSCLC), the
presence of the epidermal growth factor receptor (EGFR) mutation is associated with a better …

[PDF][PDF] Mifepristone repurposing in treatment of high-grade gliomas

M Llaguno-Munive, MI Vazquez-Lopez… - Frontiers in …, 2021 - frontiersin.org
Glioma is the most common and aggressive primary tumor of the central nervous system.
The standard treatment for malignant gliomas is surgery followed by chemoradiotherapy …

Stress sensing within the breast tumor microenvironment: how glucocorticoid receptors live in the moment

CP Kerkvliet, TH Truong, JH Ostrander… - Essays in …, 2021 - portlandpress.com
The classification and treatment of breast cancer is largely defined by the expression of
steroid hormone receptors (HRs), namely estrogen receptor (ER) and progesterone receptor …

Effect of eye movement training on sleep quality of patients with advanced lung cancer based on pittsburgh sleep quality index

H Hu, W Yang, Z Liu, X Zhang, J Shi… - Journal of healthcare …, 2021 - Wiley Online Library
Objective. To explore the effect of eye movement training on sleep quality of patients with
advanced lung cancer based on the Pittsburgh Sleep Quality Index (PSQI). Methods. 120 …