In glaucoma, lowered intraocular pressure (IOP) confers neuroprotection. Elevated IOP
characterizes glaucoma and arises from impaired aqueous humor (AH) outflow. Increased …

Glaucoma remains only partially understood, particularly at the level of intraocular pressure
(IOP) regulation. Trabecular meshwork (TM) and Schlemm's canal inner wall endothelium …

Purpose: Netarsudil is a Rho kinase/norepinephrine transporter inhibitor currently in phase
3 clinical development for glaucoma treatment. We investigated the effects of its active …

Purpose To investigate conjunctival and intrascleral vasculatures using anterior segment
optical coherence tomography angiography (AS-OCTA) in normal eyes. Design Cross …

The cause of the elevated outflow resistance and consequent ocular hypertension
characteristic of glaucoma is unknown. To investigate possible causes for this flow …

Purpose To study changes in aqueous humor outflow (AHO) patterns after trabecular
microbypass (TMB) in glaucoma patients using intraoperative sequential aqueous …

Purpose: To evaluate aqueous humor outflow (AHO) in intact eyes of live human subjects
during cataract surgery using fluorescein aqueous angiography. Methods: Aqueous …

Purpose To evaluate the feasibility of safely performing aqueous angiography in intact eyes
of living nonhuman primates (NHPs) for evaluating aqueous humor outflow and segmental …

Purpose: The extracellular matrix (ECM) of the trabecular meshwork (TM) modulates
resistance to aqueous humor outflow, thereby regulating IOP. Glaucoma, a leading cause of …

Purpose: To assess the ability of trabecular micro-bypass stents to improve aqueous humor
outflow (AHO) in regions initially devoid of AHO as assessed by aqueous angiography …