Using a sigmoidoscopy-based case-control study (753 cases, 799 controls) in Los Angeles
County, we investigated the potential modifier role in the effect of alcohol and smoking of …

Purpose The repair enzyme RAD18 plays a key role in the post-replication repair process in
various organisms from yeast to human, and the molecular function of the RAD18 protein …

Cancers of the upper aerodigestive tract (UADT), comprising the oral cavity, pharynx, larynx
and oesophagus, account for 5.2% of all cancers cases worldwide. The major risk factors …

DNA damage is an important mechanism in carcinogenesis, so genes related to maintaining
genomic integrity may influence papillary thyroid cancer (PTC) risk. Candidate gene studies …

AIM: To investigate associations between the Rsa I polymorphism of CYP2E1 and risk of
colorectal cancer. METHODS: A case-control study was conducted with 315 colorectal …

Background and objective: Carcinoma of cervix is the second most common cancer among
women worldwide. The DNA repair network plays an important role in the maintenance of …

Background: XRCC2 and XRCC3 genes are structurally and functionally related to RAD51
which plays an important role in homologous recombination, the process frequently involved …

J Oral Pathol Med (2013) 42: 180–185 Background: The capacity for DNA repair is essential
in maintaining cellular functions and homeostasis; however, this capacity can be altered …

The DNA repair protein, O6-methylguanine DNA-methyltransferase (MGMT) prevents
mutations and cell death that result from aberrant alkylation of DNA. The polymorphic …

O 6-methylguanine-DNA methyltransferase is one of the rare proteins to directly remove
alkylating agents in the human DNA direct reversal repair pathway. Its two common single …