MGMT Leu84Phe polymorphism contributes to cancer susceptibility: evidence from 44 case-control studies
J Liu, R Zhang, F Chen, C Yu, Y Sun, C Jia, L Zhang… - PLoS …, 2013 - journals.plos.org
Background O6-methylguanine-DNA methyltransferase is one of the few proteins to directly
remove alkylating agents in the human DNA direct reversal repair pathway. A large number …
remove alkylating agents in the human DNA direct reversal repair pathway. A large number …
Differential inactivation of polymorphic variants of human O6-alkylguanine-DNA alkyltransferase
Q Fang, NA Loktionova, RC Moschel… - Biochemical …, 2008 - Elsevier
The human DNA repair protein O6-alkylguanine-DNA alkyltransferase (hAGT) is an
important source of resistance to some therapeutic alkylating agents and attempts to …
important source of resistance to some therapeutic alkylating agents and attempts to …
O6‐methylguanine‐DNA methyltransferase gene coding region polymorphisms and oral cancer risk
SH Huang, PY Chang, CJ Liu, MW Lin… - Journal of oral …, 2010 - Wiley Online Library
J Oral Pathol Med (2010) 39: 645–650 Background: O 6‐methylguanine‐DNA
methyltransferase (MGMT) is a specific DNA direct reversal repair protein which ameliorates …
methyltransferase (MGMT) is a specific DNA direct reversal repair protein which ameliorates …
Meta-analysis of haplotype-association studies: comparison of methods and empirical evaluation of the literature
PG Bagos - BMC genetics, 2011 - Springer
Background Meta-analysis is a popular methodology in several fields of medical research,
including genetic association studies. However, the methods used for meta-analysis of …
including genetic association studies. However, the methods used for meta-analysis of …
Association between XRCC3 Thr241Met polymorphism and laryngeal cancer susceptibility in Turkish population
DNA repair systems are essential for normal cell function. Genetic alterations in the DNA
repair genes such as X-ray repair cross-complementing group 3 (XRCC3), can cause a …
repair genes such as X-ray repair cross-complementing group 3 (XRCC3), can cause a …
[PDF][PDF] Genetic polymorphism of DNA repair genes (XRCC1, XRCC2 & XRCC3) in breast cancer patients from rural Maharashtra
KD Datkhile, SJ Bhosale, MN Patil, TS Khamkar… - Int J Health Sci …, 2017 - academia.edu
ABSTRACT Background & Objectives: Breast cancer is a major concern of health risk,
moreover the leading cause of cancer causing deaths in women of rural parts of India. In this …
moreover the leading cause of cancer causing deaths in women of rural parts of India. In this …
Molecular epidemiology of DNA repair and cancer susceptibility—A review of population-based studies
Z Hu, LE Wang, Q Wei - DNA repair, genetic instability, and cancer, 2007 - World Scientific
The role of DNA repair in the etiology of cancer has been well illustrated in several
hereditary syndromes, in which an inherited defect in DNA repair is associated with an …
hereditary syndromes, in which an inherited defect in DNA repair is associated with an …
[PDF][PDF] Identification and application of biomarkers in molecular and genomic epidemiologic research
Biomarkers are characteristic biological properties that can be detected and measured in a
variety of biological matrices in the human body, including the blood, urine and tissue, to …
variety of biological matrices in the human body, including the blood, urine and tissue, to …
[PDF][PDF] Role of polymorphisms in cancer susceptibility
Genetic variations or polymorphisms existing in the human genome can confer genetic
susceptibility to cancer. Rare early onset cancer predisposition syndromes such as Li …
susceptibility to cancer. Rare early onset cancer predisposition syndromes such as Li …