Beginning with the sixth decade of life, the human immune system undergoes dramatic
aging-related changes, which continuously progress to a state of immunosenescence. The …

Telomeres are the heterochromatic repeat regions at the ends of eukaryotic chromosomes,
whose length is considered to be a determinant of biological ageing. Normal ageing itself is …

Inflammation and fibrosis are intertwined mechanisms fundamentally involved in heart
failure. Detailed deciphering gene expression perturbations and cell–cell interactions of …

Numerous reports of vascular events after an initial recovery from COVID-19 form our
impetus to investigate the impact of COVID-19 on vascular health of recovered patients. We …

Autoimmune vasculitis of the medium and large elastic arteries can cause blindness, stroke,
aortic arch syndrome, and aortic aneurysm. The disease is often refractory to …

Atherosclerosis is a chronic inflammatory disease that is initiated by the retention and
accumulation of cholesterol-containing lipoproteins, particularly low-density lipoprotein, in …

Inflammation is a hallmark and potent driver of pathological vascular remodelling in
atherosclerosis. However, current anti-inflammatory therapeutic strategies have shown …

Background Rheumatic disease and heart disease share common underpinnings involving
inflammation. The high levels of inflammation that characterize rheumatic diseases provide …

A large body of evidence produced during decades of research indicates that myocardial
injury activates innate immunity. On the one hand, innate immunity both aggravates …

Background—C-reactive protein (CRP) and interleukin (IL)-6 are important risk factors for
atherosclerosis and coronary heart disease. In the present study, we examined serum levels …