[HTML][HTML] Crosstalk between Wnt/β-Catenin and NF-κB signaling pathway during inflammation

B Ma, MO Hottiger - Frontiers in immunology, 2016 - frontiersin.org
Besides its important role in embryonic development and homeostatic self-renewal in adult
tissues, Wnt/β-catenin signaling exerts both anti-inflammatory and proinflammatory …

The age‐related changes in cartilage and osteoarthritis

YP Li, XC Wei, JM Zhou, L Wei - BioMed research international, 2013 - Wiley Online Library
Osteoarthritis (OA) is closely associated with aging, but its underlying mechanism is unclear.
Recent publications were reviewed to elucidate the connection between aging and OA. With …

[HTML][HTML] Inhibition of Wnt/β-catenin signaling ameliorates osteoarthritis in a murine model of experimental osteoarthritis

C Lietman, B Wu, S Lechner, A Shinar, M Sehgal… - JCI insight, 2018 - ncbi.nlm.nih.gov
Osteoarthritis (OA) is a degenerative joint disease involving both cartilage and synovium.
The canonical Wnt/β-catenin pathway, which is activated in OA, is emerging as an important …

[HTML][HTML] Onset and progression of human osteoarthritis—Can growth factors, inflammatory cytokines, or differential miRNA expression concomitantly induce …

KA Boehme, B Rolauffs - International journal of molecular sciences, 2018 - mdpi.com
Osteoarthritis (OA) is a degenerative whole joint disease, for which no preventative or
therapeutic biological interventions are available. This is likely due to the fact that OA …

WNT/β-catenin signaling induces IL-1β expression by alveolar epithelial cells in pulmonary fibrosis

V Aumiller, N Balsara, J Wilhelm, A Günther… - American journal of …, 2013 - atsjournals.org
Idiopathic pulmonary fibrosis (IPF) is a lethal lung disease of unknown etiology. It is
characterized by alterations of the alveolar epithelium, myofibroblast activation, and …

To Wnt or not to Wnt: the bone and joint health dilemma

RJ Lories, M Corr, NE Lane - Nature Reviews Rheumatology, 2013 - nature.com
The Wnt signalling cascades have essential roles in development, growth and homeostasis
of joints and the skeleton. Progress in basic research, particularly relating to our …

[HTML][HTML] Wnt16 signaling is required for il-1β-induced matrix metalloproteinase-13-regulated proliferation of human stem cell-derived osteoblastic cells

N Ozeki, M Mogi, N Hase, T Hiyama… - International journal of …, 2016 - mdpi.com
We established a differentiation method for homogeneous α7 integrin-positive human
skeletal muscle stem cell (α7+ hSMSC)-derived osteoblast-like (α7+ hSMSC-OB) cells, and …

[HTML][HTML] Drug discovery of sclerostin inhibitors

S Yu, D Li, N Zhang, S Ni, M Sun, L Wang… - … Pharmaceutica Sinica B, 2022 - Elsevier
Sclerostin, a protein secreted from osteocytes, negatively regulates the WNT signaling
pathway by binding to the LRP5/6 co-receptors and further inhibits bone formation and …

[HTML][HTML] GDF5 reduces MMP13 expression in human chondrocytes via DKK1 mediated canonical Wnt signaling inhibition

L Enochson, J Stenberg, M Brittberg… - Osteoarthritis and Cartilage, 2014 - Elsevier
Objective Growth differentiation factor 5 (GDF5) is important for joint formation and
associated with osteoarthritis (OA). Its role for the homeostasis of cartilage extracellular …

Crosstalk between Wnt/β-catenin signaling and NF-κB signaling contributes to apical periodontitis

X Guan, Y He, Z Wei, C Shi, Y Li, R Zhao, L Pan… - International …, 2021 - Elsevier
In physiology conditions, the crosstalk of signaling pathways has been considered to extend
the functions of individual pathways and results in a more complex regulatory network. The …