5-HT receptors expressed throughout the human body are targets for established
therapeutics and various drugs in development. Their diversity of structure and function …

Serotonin (5-hydroxytryptamine, 5-HT) is acknowledged as a major neuromodulator of
nervous systems in both invertebrates and vertebrates. It has been proposed for several …

Since our review of central 5-HT receptors and their function twenty years ago, no new 5-HT
receptor has been discovered and there is little evidence that this situation will change in the …

The widespread abuse of prescription opioids and a dramatic increase in the availability of
illicit opioids have created what is commonly referred to as the opioid epidemic. The …

With their ever-growing prevalence, obesity and diabetes represent major health threats of
our society. Based on estimations by the World Health Organization, approximately 300 …

The persistence of drug taking despite its adverse consequences plays a central role in the
presentation, diagnosis, and impacts of addiction. Eventual recognition and appraisal of …

Since their discovery in the mammalian brain, it has been apparent that serotonin (5-HT)
and dopamine (DA) interactions play a key role in normal and abnormal behavior …

Food addiction is considered an important link for a better understanding of psychiatric and
medical problems triggered by dysfunctions of eating behaviors, eg, obesity, metabolic …

Developmental and epileptic encephalopathies are rare, treatment-resistant epilepsies with
high seizure burden and non-seizure comorbidities. The antiseizure medication (ASM) …

Introduction Emerging evidence suggests that psychedelic compounds, including the
Amazonian botanical decoction ayahuasca, may provide clinical benefit in the treatment of …