RNA‐binding proteins, neural development and the addictions
Transcriptional and post‐transcriptional regulation of gene expression defines the
neurobiological mechanisms that bridge genetic and environmental risk factors with …
neurobiological mechanisms that bridge genetic and environmental risk factors with …
Targeting the 5-HT2C receptor in biological context and the current state of 5-HT2C receptor ligand development
Serotonin (5-HT) 5-HT2C receptor (5-HT2CR) is recognized as a critical mediator of
diseaserelated pathways and behaviors based upon actions in the central nervous system …
diseaserelated pathways and behaviors based upon actions in the central nervous system …
The serotonin 5-HT2C receptor and the non-addictive nature of classic hallucinogens
CE Canal, KS Murnane - Journal of Psychopharmacology, 2017 - journals.sagepub.com
Classic hallucinogens share pharmacology as serotonin 5-HT2A, 5-HT2B, and 5-HT2C
receptor agonists. Unique among most other Schedule 1 drugs, they are generally non …
receptor agonists. Unique among most other Schedule 1 drugs, they are generally non …
[HTML][HTML] 5-HT2C receptor blockade reverses SSRI-associated basal ganglia dysfunction and potentiates therapeutic efficacy
EY Demireva, D Suri, E Morelli, D Mahadevia… - Molecular …, 2020 - nature.com
Abstract Serotonin (5-HT) selective reuptake inhibitors (SSRIs) are widely used in the
treatment of depression and anxiety disorders, but responsiveness is uncertain and side …
treatment of depression and anxiety disorders, but responsiveness is uncertain and side …
Serotonin's complex role in alcoholism: Implications for treatment and future research
CA Marcinkiewcz, EG Lowery‐Gionta… - Alcoholism: Clinical …, 2016 - Wiley Online Library
Current pharmacological treatments for alcohol dependence have focused on reducing
alcohol consumption, but to date there are few treatments that also address the negative …
alcohol consumption, but to date there are few treatments that also address the negative …
Lorcaserin reduces the discriminative stimulus and reinforcing effects of cocaine in rhesus monkeys
GT Collins, LR Gerak, MA Javors, CP France - Journal of Pharmacology and …, 2016 - ASPET
Cocaine abuse and obesity are serious public health problems, and studies suggest that
both dopamine and serotonin systems are involved in regulating the consumption of drugs …
both dopamine and serotonin systems are involved in regulating the consumption of drugs …
The central serotonin2B receptor as a new pharmacological target for the treatment of dopamine-related neuropsychiatric disorders: Rationale and current status of …
C Devroye, A Cathala, PV Piazza… - Pharmacology & …, 2018 - Elsevier
Abstract The serotonin 2B receptor (5-HT 2B R), which was first cloned and characterized in
the rat stomach fundus, is the most recent addition to the 5-HT 2 R family. While its …
the rat stomach fundus, is the most recent addition to the 5-HT 2 R family. While its …
[HTML][HTML] Reward-induced eating: therapeutic approaches to addressing food cravings
CJ Rebello, FL Greenway - Advances in Therapy, 2016 - Springer
The homeostatic controls over eating are inextricably linked to the reward aspects of eating.
The result is an integrated response that coordinates the internal milieu with the prevailing …
The result is an integrated response that coordinates the internal milieu with the prevailing …
Lorcaserin bidirectionally regulates dopaminergic function site-dependently and disrupts dopamine brain area correlations in rats
P De Deurwaerdère, M Ramos, R Bharatiya… - …, 2020 - Elsevier
Lorcaserin, which is a selective agonist of serotonin2C receptors (5-HT 2C Rs), is a new
FDA-approved anti-obesity drug that has also shown therapeutic promise in other brain …
FDA-approved anti-obesity drug that has also shown therapeutic promise in other brain …
Role of impulsivity and reward in the anti-obesity actions of 5-HT2C receptor agonists
GA Higgins, FD Zeeb… - Journal of …, 2017 - journals.sagepub.com
The selective 5-HT2C receptor agonist lorcaserin entered clinical obesity trials with the
prevalent view that satiety was a primary mechanism of action. Subsequent Phase II and III …
prevalent view that satiety was a primary mechanism of action. Subsequent Phase II and III …