Transcriptional and post‐transcriptional regulation of gene expression defines the
neurobiological mechanisms that bridge genetic and environmental risk factors with …

Serotonin (5-HT) 5-HT2C receptor (5-HT2CR) is recognized as a critical mediator of
diseaserelated pathways and behaviors based upon actions in the central nervous system …

Classic hallucinogens share pharmacology as serotonin 5-HT2A, 5-HT2B, and 5-HT2C
receptor agonists. Unique among most other Schedule 1 drugs, they are generally non …

Abstract Serotonin (5-HT) selective reuptake inhibitors (SSRIs) are widely used in the
treatment of depression and anxiety disorders, but responsiveness is uncertain and side …

Current pharmacological treatments for alcohol dependence have focused on reducing
alcohol consumption, but to date there are few treatments that also address the negative …

Cocaine abuse and obesity are serious public health problems, and studies suggest that
both dopamine and serotonin systems are involved in regulating the consumption of drugs …

Abstract The serotonin 2B receptor (5-HT 2B R), which was first cloned and characterized in
the rat stomach fundus, is the most recent addition to the 5-HT 2 R family. While its …

The homeostatic controls over eating are inextricably linked to the reward aspects of eating.
The result is an integrated response that coordinates the internal milieu with the prevailing …

Lorcaserin, which is a selective agonist of serotonin2C receptors (5-HT 2C Rs), is a new
FDA-approved anti-obesity drug that has also shown therapeutic promise in other brain …

The selective 5-HT2C receptor agonist lorcaserin entered clinical obesity trials with the
prevalent view that satiety was a primary mechanism of action. Subsequent Phase II and III …