Objectives These experiments examined the effects of selective 5-HT 1A, 5-HT 2A and 5-HT
2C receptor ligands on responding for a conditioned reinforcer (CRf). Effects of these …

The syntheses, structure-activity relationships (SARs), and biological activities of
tetrahydroquinoline-based tricyclic amines as 5-HT 2C receptor agonists are reported. An …

While exploring the structure–activity relationship of 4-phenyl-2-dimethylaminotetralins
(PATs) at serotonin 5-HT2C receptors, we discovered that relatively minor modification of …

Asymmetric syntheses of N-protected (R)-4-halo-6, 6a, 7, 8, 9, 10-hexahydro-5H-pyrazino [1,
2-a][1, n] naphthyridines, advanced intermediates for the synthesis of highly potent and …

Rats are highly social animals and communicate through whistle-like ultrasonic
vocalizations (USVs). Typically, three main types of USVs are distinguished based on …

Substance-use disorder: A diagnostic term in the fifth edition of the Diagnostic and Statistical
Manual of Mental Disorders (DSM-5) referring to recurrent use of alcohol or other drugs that …

Aims Treatment with saikosaponin A (SSA)—an ingredient of the medicinal herb, Bupleurum
falcatum—has been reported to suppress several addictive-like behaviors, including …

ABSTRACT Background and Objective Cannabis Use Disorder (CUD) has no FDA-
approved treatment. Serotonin-2c (5HT2c) agonists have preclinical and human laboratory …

Background Lorcaserin is an anti-obesity drug whose weight loss effect results from 5-
hydroxytryptamin (5-HT) 2C receptors activation. The 5-HT2C receptor was shown to …

Traditional use of psychedelics has historically remained restricted between religious
ceremonies and countercultural movements. With the pathophysiology of various …