A series of novel (R)-6, 6a, 7, 8, 9, 10-hexahydro-5H-pyrazino [1, 2-a][1, n] naphthyridines
were identified as potent and selective agonists of the 5-HT 2C receptor. Optimizations …

Fragile X syndrome (FXS), caused by FMR1 gene silencing and subsequent loss of the RNA-
binding protein FMRP, is the leading monogenic cause of intellectual disability and autism …

In the current issue of ACS Chemical Neuroscience, Kim et al. report on the early
characterization of 4-(3-[18F] fluorophenethoxy) pyrimidine (18F-FPP) as a new positron …

Obesity is pandemic and a multidisciplinary approach is critical for its management. Anti-
obesity treatment includes lifestyle modifications combined with anti-obesity medications …

University of Birmingham Lisdexamfetamine and binge-eating disorder Page 1 University of
Birmingham Lisdexamfetamine and binge-eating disorder Schneider, Elizabeth; Higgs …

BACKGROUND/SCIENTIFIC RATIONALE Despite declines in smoking prevalence in the
United States, the likelihood of successfully quitting smoking has not improved [1, 2] …

The discovery of G protein-coupled receptors (GPCRs) and the extensive second
messenger systems associated with their activation has ushered in an enormously …

4. Design, Synthesis, and Pharmacological Characterization of Serotonin (5-HT) 5-HT2C
Receptor (5-HT2CR) Positive Allosteric Modulators Design, Synthesis, and Pharmacological …

La obesidad y sus complicaciones son unos de los grandes problemas a los que se
enfrenta un clínico actualmente. La gran mayoría de los tratamientos implementados tienen …

Addiction is associated with inflexible, rigid decision making that may, in part, underlie the
compulsive patterns of drug use that are characteristic of the disorder. One of the most …