Novel (R)-6, 6a, 7, 8, 9, 10-hexahydro-5H-pyrazino [1, 2-a][1, n] naphthyridines as potent and selective agonists of the 5-HT2C receptor
TO Schrader, X Zhu, M Kasem, A Ren, C Liu… - Bioorganic & Medicinal …, 2021 - Elsevier
A series of novel (R)-6, 6a, 7, 8, 9, 10-hexahydro-5H-pyrazino [1, 2-a][1, n] naphthyridines
were identified as potent and selective agonists of the 5-HT 2C receptor. Optimizations …
were identified as potent and selective agonists of the 5-HT 2C receptor. Optimizations …
Preclinical Development of a Novel Serotonin Receptor Modulator for Fragile X Syndrome
JL Armstrong - 2023 - search.proquest.com
Fragile X syndrome (FXS), caused by FMR1 gene silencing and subsequent loss of the RNA-
binding protein FMRP, is the leading monogenic cause of intellectual disability and autism …
binding protein FMRP, is the leading monogenic cause of intellectual disability and autism …
18F-FPP: A PET Ligand for the 5-HT2C Receptor?
GA Higgins - ACS Chemical Neuroscience, 2017 - ACS Publications
In the current issue of ACS Chemical Neuroscience, Kim et al. report on the early
characterization of 4-(3-[18F] fluorophenethoxy) pyrimidine (18F-FPP) as a new positron …
characterization of 4-(3-[18F] fluorophenethoxy) pyrimidine (18F-FPP) as a new positron …
[HTML][HTML] Existing and Emerging Molecular Targets for the Pharmacotherapy of Obesity
S Glykofrydi, A Kokkinos, TM Barber, G Mastorakos… - 2015 - europepmc.org
Obesity is pandemic and a multidisciplinary approach is critical for its management. Anti-
obesity treatment includes lifestyle modifications combined with anti-obesity medications …
obesity treatment includes lifestyle modifications combined with anti-obesity medications …
[PDF][PDF] Lisdexamfetamine and binge-eating disorder
E Schneider, S Higgs, CT Dourish - research.birmingham.ac.uk
University of Birmingham Lisdexamfetamine and binge-eating disorder Page 1 University of
Birmingham Lisdexamfetamine and binge-eating disorder Schneider, Elizabeth; Higgs …
Birmingham Lisdexamfetamine and binge-eating disorder Schneider, Elizabeth; Higgs …
[PDF][PDF] UNM IRB PROTOCOL
E Claus, C Hendershot - classic.clinicaltrials.gov
BACKGROUND/SCIENTIFIC RATIONALE Despite declines in smoking prevalence in the
United States, the likelihood of successfully quitting smoking has not improved [1, 2] …
United States, the likelihood of successfully quitting smoking has not improved [1, 2] …
Small Molecule Allosteric Modulation of G Protein-Coupled Receptors and Applications in the Pharmacological Targeting of 5-HT2 Receptors
EA Wold - 2021 - utmb-ir.tdl.org
The discovery of G protein-coupled receptors (GPCRs) and the extensive second
messenger systems associated with their activation has ushered in an enormously …
messenger systems associated with their activation has ushered in an enormously …
Design, Synthesis, and Pharmacological Characterization of Serotonin (5-HT) 5-HT2C Receptor (5-HT2CR) Positive Allosteric Modulators
CT Wild - 2021 - utmb-ir.tdl.org
4. Design, Synthesis, and Pharmacological Characterization of Serotonin (5-HT) 5-HT2C
Receptor (5-HT2CR) Positive Allosteric Modulators Design, Synthesis, and Pharmacological …
Receptor (5-HT2CR) Positive Allosteric Modulators Design, Synthesis, and Pharmacological …
Semejanzas entre obesidad y dependencia a sustancias: señalamiento de la clínica y la neurobiología en común
D Tripodi - Vertex Revista Argentina de Psiquiatría, 2018 - revistavertex.com.ar
La obesidad y sus complicaciones son unos de los grandes problemas a los que se
enfrenta un clínico actualmente. La gran mayoría de los tratamientos implementados tienen …
enfrenta un clínico actualmente. La gran mayoría de los tratamientos implementados tienen …
Investigating the computational underpinnings of addiction
SM Groman - Neuropsychopharmacology, 2019 - nature.com
Addiction is associated with inflexible, rigid decision making that may, in part, underlie the
compulsive patterns of drug use that are characteristic of the disorder. One of the most …
compulsive patterns of drug use that are characteristic of the disorder. One of the most …