Deregulated mitochondrial microRNAs in Alzheimer's disease: focus on synapse and mitochondria
Alzheimer's disease (AD) is the most common cause of dementia and is currently one of the
biggest public health concerns in the world. Mitochondrial dysfunction in neurons is one of …
biggest public health concerns in the world. Mitochondrial dysfunction in neurons is one of …
The role of noncoding RNAs in Parkinson's disease: biomarkers and associations with pathogenic pathways
MC Kuo, SCH Liu, YF Hsu, RM Wu - Journal of biomedical science, 2021 - Springer
The discovery of various noncoding RNAs (ncRNAs) and their biological implications is a
growing area in cell biology. Increasing evidence has revealed canonical and noncanonical …
growing area in cell biology. Increasing evidence has revealed canonical and noncanonical …
Current status of microRNA-based therapeutic approaches in neurodegenerative disorders
S Paul, LA Bravo Vázquez, S Pérez Uribe… - Cells, 2020 - mdpi.com
MicroRNAs (miRNAs) are a key gene regulator and play essential roles in several biological
and pathological mechanisms in the human system. In recent years, plenty of miRNAs have …
and pathological mechanisms in the human system. In recent years, plenty of miRNAs have …
Naringenin alleviates paraquat-induced dopaminergic neuronal loss in SH-SY5Y cells and a rat model of Parkinson's disease
Abstract Parkinson's disease (PD), a common neurodegenerative disease is characterized
by the progressive loss of dopaminergic neurons in the substantia nigra. The cause of …
by the progressive loss of dopaminergic neurons in the substantia nigra. The cause of …
[HTML][HTML] Targeting mitochondrial impairment in Parkinson's disease: challenges and opportunities
The underlying pathophysiology of Parkinson's disease is complex, but mitochondrial
dysfunction has an established and prominent role. This is supported by an already large …
dysfunction has an established and prominent role. This is supported by an already large …
Molecular biomarkers and their implications for the early diagnosis of selected neurodegenerative diseases
J Doroszkiewicz, M Groblewska, B Mroczko - International Journal of …, 2022 - mdpi.com
The degeneration and dysfunction of neurons are key features of neurodegenerative
diseases (NDs). Currently, one of the main challenges facing researchers and clinicians is …
diseases (NDs). Currently, one of the main challenges facing researchers and clinicians is …
Roles of clock genes in the pathogenesis of Parkinson's disease
AD Shkodina, SC Tan, MM Hasan… - Ageing Research …, 2022 - Elsevier
Parkinson's disease (PD) is a common motor disorder that has become increasingly
prevalent in the ageing population. Recent works have suggested that circadian rhythms …
prevalent in the ageing population. Recent works have suggested that circadian rhythms …
Integration of miRNA's theranostic potential with nanotechnology: promises and challenges for Parkinson's disease therapeutics
Despite the wide research going on in Parkinson's disease (PD), the burden of PD still
remains high and continues to increase. The current drugs available for the treatment of PD …
remains high and continues to increase. The current drugs available for the treatment of PD …
Unraveling the role of miRNAs in the diagnosis, progression, and therapeutic intervention of Parkinson's disease
Parkinson's disease (PD) is a debilitating neurological disorder characterized by the
impairment of the motor system, resulting in symptoms such as resting tremor, cogwheel …
impairment of the motor system, resulting in symptoms such as resting tremor, cogwheel …
High mobility group box 1 in human cancer
High mobility group box 1 (HMGB1) is an extremely versatile protein that is located
predominantly in the nucleus of quiescent eukaryotic cells, where it is critically involved in …
predominantly in the nucleus of quiescent eukaryotic cells, where it is critically involved in …