The molecular mechanisms of sarcomere proteins underlie the contractile function of the
heart. Although our understanding of the sarcomere has grown tremendously, the focus has …

Omecamtiv mecarbil (OM) is a novel inotropic agent for heart failure with systolic
dysfunction. OM prolongs the actomyosin attachment duration, which enhances thin filament …

In this study, we investigated the rescue potential of two phosphomimetic mutants of the
myosin regulatory light chain (RLC, MYL2 gene), S15D, and T160D RLCs. S15D-RLC …

Fundamentally, the heart needs to generate sufficient force and power output to dynamically
meet the needs of the body. Cardiomyocytes contain specialized structures referred to as …

In this study, we aimed to investigate whether short-term and low-dose treatment with
hydroxychloroquine (HCQ), an antimalarial drug, can modulate heart function in a preclinical …

The physiological importance of cardiac myosin regulatory light chain (RLC)
phosphorylation by its dedicated cardiac myosin light chain kinase has been established in …

There is a growing awareness that both thick filament and classical thin filament regulation
play central roles in modulating muscle contraction. Myosin ATPase assays have …

This study focuses on mimicking constitutive phosphorylation in the N-terminus of the
myosin regulatory light chain (S15D-RLC) as a rescue strategy for mutation-induced cardiac …

We investigated the impact of the phosphomimetic (Ser15→ Asp15) myosin regulatory light
chain (S15D‐RLC) on the Super‐Relaxed (SRX) state of myosin using previously …

Formation of the auto-inhibited super-relaxed (SRX) state of cardiac myosin is thought to be
crucial for regulating contraction, relaxation, and energy conservation in the heart. We found …