Targeting brain Renin-Angiotensin System for the prevention and treatment of Alzheimer's disease: Past, present and future
F Gouveia, A Camins, M Ettcheto, J Bicker… - Ageing Research …, 2022 - Elsevier
Alzheimer's disease (AD) is a well-known neurodegenerative disease characterized by the
presence of two main hallmarks–Tau hyperphosphorylation and Aβ deposits …
presence of two main hallmarks–Tau hyperphosphorylation and Aβ deposits …
Streptozotocin intracerebroventricular-induced neurotoxicity and brain insulin resistance: a therapeutic intervention for treatment of sporadic Alzheimer's disease (sAD …
Alzheimer's disease (AD) is a neurodegenerative disorder that is remarkably characterized
by pathological hallmarks which include amyloid plaques, neurofibrillary tangles, neuronal …
by pathological hallmarks which include amyloid plaques, neurofibrillary tangles, neuronal …
Novel luteolin-loaded chitosan decorated nanoparticles for brain-targeting delivery in a sporadic Alzheimer's disease mouse model: Focus on antioxidant, anti …
H Abbas, NSE Sayed, NAHA Youssef, P ME Gaafar… - Pharmaceutics, 2022 - mdpi.com
Preparation and evaluation of a non-invasive intranasal luteolin delivery for the
management of cognitive dysfunction in Alzheimer's disease (AD) using novel chitosan …
management of cognitive dysfunction in Alzheimer's disease (AD) using novel chitosan …
Linagliptin, a DPP-4 inhibitor, ameliorates Aβ (1− 42) peptides induced neurodegeneration and brain insulin resistance (BIR) via insulin receptor substrate-1 (IRS-1) in …
Alzheimer's disease (AD) is the most devastating neurodegenerative disorder, accounting
over 46 million cases of dementia globally. Evidence supports that Brain Insulin Resistance …
over 46 million cases of dementia globally. Evidence supports that Brain Insulin Resistance …
RETRACTED ARTICLE: protective effects of gingerol on streptozotocin-induced sporadic Alzheimer's disease: emphasis on inhibition of β-amyloid, COX-2, alpha …
AME Halawany, NSEL Sayed, HM Abdallah… - Scientific Reports, 2017 - nature.com
Gingerol is a major dietary compound that occurs in several plants belonging to the
Zingiberaceae family. In the current study, the protective effect of gingerol on STZ-induced …
Zingiberaceae family. In the current study, the protective effect of gingerol on STZ-induced …
[HTML][HTML] Hibiscus sabdariffa L.: A potent natural neuroprotective agent for the prevention of streptozotocin-induced Alzheimer's disease in mice
Hibiscus sabdariffa L.(Malvaceae) is one of the well-known traditionally used remedy
worldwide. It exhibited numerous pharmacological properties including antioxidant …
worldwide. It exhibited numerous pharmacological properties including antioxidant …
Diabetes: Risk factor and translational therapeutic implications for Alzheimer's disease
J Cummings, A Ortiz, J Castellino… - European Journal of …, 2022 - Wiley Online Library
Type 2 diabetes mellitus (T2DM) and Alzheimer's disease (AD) commonly co‐occur. T2DM
increases the risk for AD by approximately twofold. Animal models provide one means of …
increases the risk for AD by approximately twofold. Animal models provide one means of …
Tadalafil and bergapten mitigate streptozotocin-induced sporadic Alzheimer's disease in mice via modulating neuroinflammation, PI3K/Akt, Wnt/β-catenin, AMPK …
MA Salem, B Budzyńska, J Kowalczyk… - Toxicology and applied …, 2021 - Elsevier
Sporadic Alzheimer's disease (SAD) is a slowly progressive neurodegenerative disorder.
This study aimed to investigate neuroprotective potential of tadalafil (TAD) and bergapten …
This study aimed to investigate neuroprotective potential of tadalafil (TAD) and bergapten …
Current progress on peroxisome proliferator-activated receptor gamma agonist as an emerging therapeutic approach for the treatment of Alzheimer's disease: an …
Alzheimer's disease (AD) is an age-related progressive neurodegenerative disorder,
characterized by the deposition of amyloid-β within the brain parenchyma resulting in a …
characterized by the deposition of amyloid-β within the brain parenchyma resulting in a …
A brain-targeted approach to ameliorate memory disorders in a sporadic Alzheimer's disease mouse model via intranasal luteolin-loaded nanobilosomes
MA Elsheikh, YA El-Feky, MM Al-Sawahli, ME Ali… - Pharmaceutics, 2022 - mdpi.com
Impaired memory and cognitive function are the main features of Alzheimer's disease (AD).
Unfortunately, currently available treatments cannot cure or delay AD progression …
Unfortunately, currently available treatments cannot cure or delay AD progression …