Upon binding their cognate receptors, ERα (ESR1) and ERβ (ESR2), estrogens activate
intracellular signaling cascades that have important consequences for cellular behavior …

Colorectal cancer (CRC) is a leading cause of death in the United States. Despite its slow
development and the capacity for early diagnosis, current preventive approaches are not …

Genistein, a polyphenolic isoflavone compound found abundantly in soy or soy‐based
products, is widely consumed in the Asian population. Genistein has poor bioavailability, to …

The role of oestrogen in oncogenesis has been examined extensively, especially in the
context of breast cancer, and receptor modulators are an integral part of targeted treatment …

Estrogens have been implicated in the pathogenesis of various cancer types, including
colorectal carcinoma (CRC). Estrogen receptors such as ERα and ERβ activate intracellular …

Context—A new class of estrogen receptors was discovered in 1996 and named estrogen
receptor β (ER-B); the traditional estrogen receptor, which until a little more than 10 years …

There is a growing body of evidence that disturbed circadian clock gene expression is
associated with tumor development and tumor progression. Based on our initial experiments …

The steroid hormone receptors (SHRs) among nuclear hormone receptors (NHRs) are
steroid ligand‐dependent transcription factors that play important roles in the regulation of …

Colorectal cancer (CRC) is the second cause of cancer-related death in both sexes
worldwide. As pre-menopausal women are less likely to develop CRC compared to age …

Hormones have become a useful therapeutic aspect of clinical endocrinology but how to use
them to optimize the health benefits and avoid adverse effects is a major challenge …