Growing evidences suggest that the fibroblast growth factor/FGF receptor (FGF/FGFR)
signaling has crucial roles in a multitude of processes during embryonic development and …

Diabetes mellitus predisposes affected individuals to a significant spectrum of
cardiovascular complications, one of the most debilitating in terms of prognosis is heart …

Sodium-glucose co-transporter 2 (SGLT2) inhibitors block glucose reabsorption in the renal
proximal tubule, an insulin-independent mechanism that plays a critical role in glycemic …

The COVID-19 pandemic has been the primary global health issue since its outbreak in
December 2019. Patients with metabolic syndrome suffer from severe complications and a …

Obesity and ageing place a tremendous strain on the global healthcare system. Age-related
sarcopenia is characterized by decreased muscular strength, decreased muscle quantity …

Type 2 diabetes mellitus (T2DM) is one of the greatest health crises of our time and its
prevalence is projected to increase by> 50% globally by 2045. Currently, 10 classes of …

In a world in which life expectancy is increasing, understanding and promoting healthy
aging becomes a contemporary demand. In the elderly, a sterile, chronic and low-grade …

The mitochondria are double-membrane organelles integral for energy metabolism.
Mitochondrial dynamics is regulated by inner and outer mitochondrial membrane (IMM and …

Mitochondria, ubiquitous double-membrane-bound organelles, regulate energy production,
support cellular activities, harbor metabolic pathways, and, paradoxically, mediate cell fate …

Skeletal muscle is capable of secreting different factors in order to communicate with other
tissues. These mediators, the myokines, show potentially far-reaching effects on non-muscle …