The ongoing obesity pandemic generates a constant need to develop new therapeutic
strategies to restore the energy balance. Therefore, the concept of activating brown adipose …

Mitokines are signaling molecules that enable communication of local mitochondrial stress
to other mitochondria in distant cells and tissues. Among those molecules are FGF21 …

Background Management strategies for non-alcoholic steatohepatitis (NASH) are based
predominantly on lifestyle modification, with no approved disease-modifying drugs yet …

Regular exercise is associated with pronounced health benefits. The molecular processes
involved in physiological adaptations to exercise are best understood in skeletal muscle …

The contribution of adipose-derived FGF21 to energy homeostasis is unclear. Here we show
that browning of inguinal white adipose tissue (iWAT) by β-adrenergic agonists requires …

Physical activity reduces cardiometabolic risk, while physical inactivity increases chronic
diseases risk. This led to the idea that exercise-induced muscle contraction contributes to …

Sarcopenia is defined as a progressive and generalized skeletal muscle disorder
associated with accelerated loss of muscle mass and function, resulting in falls, functional …

Abstract Cardiovascular (CV) disease (CVD) remains the leading cause of major morbidity
and CVD-and all-cause mortality in most of the world. It is now clear that regular physical …

Comparing energy metabolism in human skeletal muscle and primary skeletal muscle cells
in obesity, while focusing on glucose and fatty acid metabolism, shows many common …

Exercise training has been reported to alleviate cardiac fibrosis and ameliorate heart
dysfunction after myocardial infarction (MI), but the molecular mechanism is still not fully …