Implications of mitochondrial fusion and fission in skeletal muscle mass and health
V Romanello, M Sandri - Seminars in cell & developmental biology, 2023 - Elsevier
The continuous dynamic reshaping of mitochondria by fusion and fission events is critical to
keep mitochondrial quality and function under control in response to changes in energy and …
keep mitochondrial quality and function under control in response to changes in energy and …
A coordinated multiorgan metabolic response contributes to human mitochondrial myopathy
N Southwell, G Primiano, V Nadkarni… - EMBO Molecular …, 2023 - embopress.org
Mitochondrial diseases are a heterogeneous group of monogenic disorders that result from
impaired oxidative phosphorylation (OXPHOS). As neuromuscular tissues are highly energy …
impaired oxidative phosphorylation (OXPHOS). As neuromuscular tissues are highly energy …
Mitochondrial DNA and inflammatory proteins are higher in extracellular vesicles from frail individuals
AM Byappanahalli, N Noren Hooten, M Vannoy… - Immunity & …, 2023 - Springer
Background Frailty, a clinical syndrome commencing at midlife, is a risk for morbidity and
mortality. Little is known about the factors that contribute to the chronic inflammatory state …
mortality. Little is known about the factors that contribute to the chronic inflammatory state …
Identification of biomarkers for physical frailty and sarcopenia through a new multi-marker approach: results from the BIOSPHERE study
Physical frailty and sarcopenia (PF&S) is a prototypical geriatric condition characterized by
reduced physical function and low muscle mass. The aim of the present study was to provide …
reduced physical function and low muscle mass. The aim of the present study was to provide …
Whole body-electromyostimulation effects on serum biomarkers, physical performances and fatigue in Parkinson's patients: A randomized controlled trial
A di Cagno, A Buonsenso, M Centorbi… - Frontiers in Aging …, 2023 - frontiersin.org
Background Whole-body electromyostimulation (WB-EMS) was never previously applied to
Parkinson's disease (PD) patients. This randomized controlled study aimed to find the most …
Parkinson's disease (PD) patients. This randomized controlled study aimed to find the most …
The integrated stress response as a key pathway downstream of mitochondrial dysfunction
M Bilen, S Benhammouda, RS Slack… - Current Opinion in …, 2022 - Elsevier
Mitochondrial function is fundamental to maintaining metabolic homeostasis. Alterations in
mitochondrial biogenesis, energy production, and dynamics are behind many metabolic …
mitochondrial biogenesis, energy production, and dynamics are behind many metabolic …
Phytochemicals from the cocoa shell modulate mitochondrial function, lipid and glucose metabolism in hepatocytes via activation of FGF21/ERK, AKT, and mTOR …
M Rebollo-Hernanz, Y Aguilera, MA Martin-Cabrejas… - Antioxidants, 2022 - mdpi.com
The cocoa shell is a by-product that may be revalorized as a source of bioactive compounds
to prevent chronic cardiometabolic diseases. This study aimed to investigate the …
to prevent chronic cardiometabolic diseases. This study aimed to investigate the …
Endurance exercise-induced Fgf21 promotes skeletal muscle fiber conversion through TGF-β1 and p38 MAPK signaling pathway
X Luo, H Zhang, X Cao, D Yang, Y Yan, J Lu… - International Journal of …, 2023 - mdpi.com
Fgf21 has been identified as playing a regulatory role in muscle growth and function.
Although the mechanisms through which endurance training regulates skeletal muscle have …
Although the mechanisms through which endurance training regulates skeletal muscle have …
Pemafibrate protects against retinal dysfunction in a murine model of diabetic retinopathy
Diabetic retinopathy (DR) is one of the leading causes of blindness globally. Retinal
neuronal abnormalities occur in the early stage in DR. Therefore, maintaining retinal …
neuronal abnormalities occur in the early stage in DR. Therefore, maintaining retinal …
Intestinal-derived FGF15 protects against deleterious effects of vertical sleeve gastrectomy in mice
N Bozadjieva-Kramer, JH Shin, Y Shao… - Nature …, 2021 - nature.com
Bariatric surgeries such as the Vertical Sleeve Gastrectomy (VSG) are invasive but provide
the most effective improvements in obesity and Type 2 diabetes. We hypothesized a …
the most effective improvements in obesity and Type 2 diabetes. We hypothesized a …