Tumours utilise tryptophan (Trp) and its metabolites to promote their growth and evade host
defences. They recruit Trp through up-regulation of Trp transporters, and up-regulate key …

Cardiovascular diseases are the leading cause of death worldwide. Aging and/or metabolic
stress directly impact the cardiovascular system. Over the last few years, the contributions of …

Abstract Coronavirus disease 2019 (COVID-19) is a recent pandemic that caused serious
global emergency. To identify new and effective therapeutics, we employed a drug …

Introduction Severe COVID-19 results initially in pulmonary infection and inflammation.
Symptoms can persist beyond the period of acute infection, and patients with Post-Acute …

ADP-ribosylation, is a reversible post-translational modification implicated in major
biological functions. Poly ADP-ribose polymerases (PARP) are specialized enzymes that …

This medical review addresses the hypothesis that CD38/NADase is at the center of a
functional axis (ie, intracellular Ca2+ mobilization/IFNγ response/reactive oxygen species …

The epithelial barrier's primary role is to protect against entry of foreign and pathogenic
elements. Both COVID-19 and Inflammatory Bowel Disease (IBD) show commonalities in …

Divergent pathways of macrophage metabolism occur during infection, notably switching
between oxidative phosphorylation and aerobic glycolysis (Warburg‐like metabolism) …

SARS-CoV-2 uses the human ACE2 (hACE2) receptor for cell attachment and entry, with
mouse ACE2 (mACE2) unable to support infection. Herein we describe an ACE2-lentivirus …

Abstract COVID-19 (CO rona VI rus D isease of 20 19), the disease caused by the severe
acute respiratory syndrome coronavirus 2 (SARS-CoV-2), represents an ongoing global …