Spirocyclic scaffolds are incorporated in various approved drugs and drug candidates. The
increasing interest in less planar bioactive compounds has given rise to the development of …

Electrochemical dearomative spirocyclization serves as a green and sustainable approach
to convert the flat, two‐dimension aromatic feedstock into the value‐added three‐dimension …

We present herein a highly diastereo-and enantioselective Pd-catalyzed [4+ 2] cycloaddition
of benzofuran-derived azadienes with vinyl benzoxazinanones, which represents a rare …

Covalent chemistry coupled with activity-based protein profiling (ABPP) offers a versatile
way to discover ligands for proteins in native biological systems. Here, we describe a set of …

Spirocyclic indole derivatives are fascinating tridimensional molecular scaffolds from both a
synthetic and a biological point of view. Among the many strategies developed to access …

A variety of acrylamides holding an unactivated N-benzyl group underwent dearomative
ipso-cyclization induced by sulfur-centered radicals (SCN/SCF3/SO2Ar) in the presence of …

A 2‐biphenylacetylene was fixed into a specific conformation within the confined cavity of a
hollow cage, where it underwent a regioselective spirocyclization in the presence of an …

This paper studies modern methods of producing and using callus, suspension cells and
root cultures of medicinal plants in vitro. A new solution for natural product production is the …

We disclose a general catalytic enantioselective Diels–Alder reaction of exo-enones with
dienes to give spirocyclanes. The obtained products feature highly congested quaternary …

Squalene-hopene cyclases (SHCs) are the biocatalytic pendant to asymmetric Brønsted-
acid catalysis and thus comprise enormous synthetic potential. Nevertheless, their substrate …