Epithelial–mesenchymal transition (EMT) is an essential process in normal embryonic
development and tissue regeneration. However, aberrant reactivation of EMT is associated …

Epithelial stem cells serve critical physiological functions in the generation, maintenance
and repair of diverse tissues through their ability to self-renew and spawn more specialized …

Contingent upon concentration, reactive oxygen species (ROS) influence cancer evolution
in apparently contradictory ways, either initiating/stimulating tumorigenesis and supporting …

The microenvironment in cancerous tissues is immunosuppressive and pro-tumorigenic,
whereas the microenvironment of tissues affected by chronic inflammatory disease is pro …

Epithelial‐mesenchymal transition (EMT) is a complex process with a primordial role in
cellular transformation whereby an epithelial cell transforms and acquires a mesenchymal …

Triple-negative breast cancer (TNBC) is an aggressive subtype associated with early
metastatic recurrence and worse patient outcomes. TNBC tumors express molecular …

Metastasis is the main cause of cancer-related mortality. Although the actual process of
metastasis remains largely elusive, epithelial-mesenchymal transition (EMT) has been …

Resistance to cancer therapy is a major barrier to cancer management. Conventional views
have proposed that acquisition of resistance may result from genetic mutations. However …

Background Solid tumors such as pancreatic ductal adenocarcinoma (PDAC) comprise not
just tumor cells but also a microenvironment with which the tumor cells constantly interact …

Cancer immunotherapies have shown clinical success in various types of tumors but the
patient response rate is low, particularly in breast cancer. Here we report that malignant …