Deterministic reprogramming of neutrophils within tumors
Neutrophils are increasingly recognized as key players in the tumor immune response and
are associated with poor clinical outcomes. Despite recent advances characterizing the …
are associated with poor clinical outcomes. Despite recent advances characterizing the …
Hypoxia-induced epithelial-mesenchymal transition in cancers: HIF-1α and beyond
Metastasis is the main cause of cancer-related mortality. Although the actual process of
metastasis remains largely elusive, epithelial-mesenchymal transition (EMT) has been …
metastasis remains largely elusive, epithelial-mesenchymal transition (EMT) has been …
In primary airway epithelial cells, the unjamming transition is distinct from the epithelial-to-mesenchymal transition
The epithelial-to-mesenchymal transition (EMT) and the unjamming transition (UJT) each
comprises a gateway to cellular migration, plasticity and remodeling, but the extent to which …
comprises a gateway to cellular migration, plasticity and remodeling, but the extent to which …
Targeting polarized phenotype of microglia via IL6/JAK2/STAT3 signaling to reduce NSCLC brain metastasis
Y Jin, Y Kang, M Wang, B Wu, B Su, H Yin… - … and Targeted Therapy, 2022 - nature.com
Tumor-associated macrophages have emerged as crucial factors for metastases. Microglia
are indispensable components of the brain microenvironment and play vital roles in brain …
are indispensable components of the brain microenvironment and play vital roles in brain …
[HTML][HTML] Apoptotic induction and anti-metastatic activity of eugenol encapsulated chitosan nanopolymer on rat glioma C6 cells via alleviating the MMP signaling …
Z Li, VP Veeraraghavan, SK Mohan, SR Bolla… - … of Photochemistry and …, 2020 - Elsevier
Glioma is the prime cause of cancer allied mortality in adolescent people and it accounts
about 80% of all malignant tumours. Eugenol is a major bioactive constituent present in the …
about 80% of all malignant tumours. Eugenol is a major bioactive constituent present in the …
Targeting glutaminolysis: new perspectives to understand cancer development and novel strategies for potential target therapies
Z Wang, F Liu, N Fan, C Zhou, D Li, T Macvicar… - Frontiers in …, 2020 - frontiersin.org
Metabolism rewiring is an important hallmark of cancers. Being one of the most abundant
free amino acids in the human blood, glutamine supports bioenergetics and biosynthesis …
free amino acids in the human blood, glutamine supports bioenergetics and biosynthesis …
MLL3 loss drives metastasis by promoting a hybrid epithelial–mesenchymal transition state
Phenotypic plasticity associated with the hybrid epithelial–mesenchymal transition (EMT) is
crucial to metastatic seeding and outgrowth. However, the mechanisms governing the hybrid …
crucial to metastatic seeding and outgrowth. However, the mechanisms governing the hybrid …
Pharmacologic Screening Identifies Metabolic Vulnerabilities of CD8+ T Cells
JM Drijvers, JE Gillis, T Muijlwijk, TH Nguyen… - Cancer immunology …, 2021 - AACR
Metabolic constraints in the tumor microenvironment constitute a barrier to effective
antitumor immunity and similarities in the metabolic properties of T cells and cancer cells …
antitumor immunity and similarities in the metabolic properties of T cells and cancer cells …
Heterogeneous microenvironmental stiffness regulates pro-metastatic functions of breast cancer cells
Besides molecular and phenotypic variations observed in cancer cells, intratumoral
heterogeneity also occurs in the tumor microenvironment. Correlative stiffness maps of …
heterogeneity also occurs in the tumor microenvironment. Correlative stiffness maps of …
The role of silver nanoparticles in the diagnosis and treatment of cancer: Are there any perspectives for the future?
P Takáč, R Michalková, M Čižmáriková, Z Bedlovičová… - Life, 2023 - mdpi.com
Cancer is a fatal disease with a complex pathophysiology. Lack of specificity and
cytotoxicity, as well as the multidrug resistance of traditional cancer chemotherapy, are the …
cytotoxicity, as well as the multidrug resistance of traditional cancer chemotherapy, are the …